Grohmann M
Institut für Pharmakologie und Toxikologie, Universität Würzburg, Federal Republic of Germany.
Naunyn Schmiedebergs Arch Pharmacol. 1988 Apr;337(4):406-7. doi: 10.1007/BF00169531.
After loading of the extraneuronal tissues of the perfused rat heart with 3H-isoprenaline the elevation of extracellular K+ concentration (from 2.7 to 15 mmol/l) in the perfusion solution about doubled the rate constant for efflux of the 3H-amine. As this increase was not seen in the presence of 100 mumol/l 3-O-methyl-isoprenaline (OMI, a potent inhibitor of the uptake2-carrier), it is concluded that the change in the concentration of K+ modulates OMI-sensitive outward transport of 3H-isoprenaline by uptake2, not the diffusional efflux of the amine.
在用3H - 异丙肾上腺素灌注大鼠心脏的神经外组织后，灌注液中细胞外钾离子浓度从2.7 mmol/L升高至15 mmol/L，这使3H - 胺的流出速率常数增加了约一倍。由于在存在100 μmol/L 3 - O - 甲基 - 异丙肾上腺素（OMI，摄取2载体的强效抑制剂）的情况下未观察到这种增加，因此得出结论，钾离子浓度的变化通过摄取2调节OMI敏感的3H - 异丙肾上腺素外向转运，而非胺的扩散流出。
