利血平治疗对大鼠心房中外神经元摄取[3H]-异丙肾上腺素的影响。
The effect of reserpine treatment on the extraneuronal uptake of [3H]-isoprenaline into rat atria.
作者信息
Morton A J
出版信息
Br J Pharmacol. 1985 Sep;86(1):287-95. doi: 10.1111/j.1476-5381.1985.tb09460.x.
Treatment of rats with reserpine (1 mg kg-1 day-1) for up to 7 days resulted in a marked decrease in a corticosterone-sensitive component of the extraneuronal accumulation of [3H]-isoprenaline into their atria. The change in extraneuronal uptake did not appear to be due to a direct action of reserpine on the uptake mechanism, since it was several days before the treatment had a significant effect on the accumulation of [3H]-isoprenaline. Further, reserpine in vitro did not inhibit extraneuronal uptake. The reserpine-induced change in the accumulation of [3H]-isoprenaline was not an artifact due to changes in water balance, ion distribution, extracellular space or tissue atrophy. Nor was the change due to an increase in the efflux of [3H]-isoprenaline from the tissue. These experiments support the suggestion that the extraneuronal uptake is dependent upon a functional adrenergic innervation.
用利血平（1毫克/千克/天）对大鼠进行长达7天的处理，导致其心房中外神经元对[3H] - 异丙肾上腺素积累的皮质酮敏感成分显著减少。外神经元摄取的变化似乎不是由于利血平对摄取机制的直接作用，因为在处理数天后才对[3H] - 异丙肾上腺素的积累产生显著影响。此外，体外利血平并不抑制外神经元摄取。利血平诱导的[3H] - 异丙肾上腺素积累变化不是由于水平衡、离子分布、细胞外空间或组织萎缩的变化所导致的假象。该变化也不是由于[3H] - 异丙肾上腺素从组织中的流出增加所致。这些实验支持了外神经元摄取依赖于功能性肾上腺素能神经支配的观点。
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