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1
The effect of reserpine treatment on the extraneuronal uptake of [3H]-isoprenaline into rat atria.利血平治疗对大鼠心房中外神经元摄取[3H]-异丙肾上腺素的影响。
Br J Pharmacol. 1985 Sep;86(1):287-95. doi: 10.1111/j.1476-5381.1985.tb09460.x.
2
A role for corticosterone in the in vivo regulation of the extraneuronal uptake of [3H]-isoprenaline into rat atria.皮质酮在体内对大鼠心房中外神经元摄取[3H]-异丙肾上腺素的调节作用。
Br J Pharmacol. 1987 Jun;91(2):347-53. doi: 10.1111/j.1476-5381.1987.tb10289.x.
3
An investigation of the role of adrenergic innervation in the regulation of the extraneuronal uptake of [3H]-isoprenaline into rat vasa deferentia and atria.肾上腺素能神经支配在调节[3H]-异丙肾上腺素向大鼠输精管和心房的非神经元摄取中的作用研究。
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4
The extraneuronal compartments for the distribution of isoprenaline in the rat heart.大鼠心脏中异丙肾上腺素分布的神经外间隙。
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5
The acceleration of the extraneuronal efflux of 3H-(+/-)-isoprenaline induced by high extracellular potassium.高细胞外钾诱导的3H-（+/-）-异丙肾上腺素细胞外流出加速。
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The fate of isoprenaline after inhibition of O-methylation and of extraneuronal uptake.在抑制O-甲基化和非神经元摄取后异丙肾上腺素的命运。
Eur J Pharmacol. 1980 Oct 17;67(2-3):247-53. doi: 10.1016/0014-2999(80)90505-1.
8
Autoradiographic study of rat hearts perfused with 3H-isoprenaline.用³H-异丙肾上腺素灌注大鼠心脏的放射自显影研究。
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The effects of acute reserpine administration on the sensitivity of the isolated pacemaker from rat heart to isoprenaline and noradrenaline.急性给予利血平对大鼠心脏离体起搏器对异丙肾上腺素和去甲肾上腺素敏感性的影响。
J Pharm Pharmacol. 1987 Aug;39(8):662-4. doi: 10.1111/j.2042-7158.1987.tb03451.x.

引用本文的文献

1
A role for corticosterone in the in vivo regulation of the extraneuronal uptake of [3H]-isoprenaline into rat atria.皮质酮在体内对大鼠心房中外神经元摄取[3H]-异丙肾上腺素的调节作用。
Br J Pharmacol. 1987 Jun;91(2):347-53. doi: 10.1111/j.1476-5381.1987.tb10289.x.
2
An investigation of the role of adrenergic innervation in the regulation of the extraneuronal uptake of [3H]-isoprenaline into rat vasa deferentia and atria.肾上腺素能神经支配在调节[3H]-异丙肾上腺素向大鼠输精管和心房的非神经元摄取中的作用研究。
Br J Pharmacol. 1987 Jun;91(2):333-46. doi: 10.1111/j.1476-5381.1987.tb10288.x.

本文引用的文献

1
THE FATE OF 3H-ISO-PROTERENOL IN THE RAT.大鼠体内3H-异丙肾上腺素的代谢情况
Biochem Pharmacol. 1964 Aug;13:1119-28. doi: 10.1016/0006-2952(64)90112-1.
2
DETERMINATION OF WATER AND ELECTROLYTES IN TISSUE SLICES.组织切片中水分和电解质的测定
Anal Biochem. 1964 Jan;7:87-95. doi: 10.1016/0003-2697(64)90122-8.
3
Fate of norepinephrine-H3 in the isolated perfused rat heart.去甲肾上腺素 - H3在离体灌注大鼠心脏中的命运。
J Pharmacol Exp Ther. 1962 Oct;138:34-40.
4
Metabolism of administered and drug-released norepinephrine-7-H3 in the rat.大鼠体内给药及药物释放的去甲肾上腺素 - 7 - H3的代谢
J Pharmacol Exp Ther. 1963 May;140:207-16.
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Reserpine-induced circulatory failure.利血平引起的循环衰竭。
Nature. 1961 Nov 11;192:521-3. doi: 10.1038/192521a0.
6
The fate of isoprenaline after inhibition of O-methylation and of extraneuronal uptake.在抑制O-甲基化和非神经元摄取后异丙肾上腺素的命运。
Eur J Pharmacol. 1980 Oct 17;67(2-3):247-53. doi: 10.1016/0014-2999(80)90505-1.
7
Uptake and O-methylation of isoprenaline in the rabbit ear artery.异丙肾上腺素在兔耳动脉中的摄取与O-甲基化作用。
Blood Vessels. 1980;17(5):229-45. doi: 10.1159/000158253.
8
Effect of moderate cooling on adrenergic neuroeffector interaction in canine cutaneous veins.适度冷却对犬皮肤静脉中肾上腺素能神经效应器相互作用的影响。
Blood Vessels. 1981;18(6):281-95. doi: 10.1159/000158361.
9
The fate of isoprenaline in the isolated rabbit aorta. Radiochemical and morphologic observations.异丙肾上腺素在离体兔主动脉中的命运。放射化学和形态学观察。
Naunyn Schmiedebergs Arch Pharmacol. 1981 Apr;316(2):120-5. doi: 10.1007/BF00505304.
10
Chronic reserpine treatment alters sensitivity and membrane potential of the rabbit saphenous artery.长期利血平治疗会改变兔隐动脉的敏感性和膜电位。
J Pharmacol Exp Ther. 1981 May;217(2):430-9.

利血平治疗对大鼠心房中外神经元摄取[3H]-异丙肾上腺素的影响。

The effect of reserpine treatment on the extraneuronal uptake of [3H]-isoprenaline into rat atria.

作者信息

Morton A J

出版信息

Br J Pharmacol. 1985 Sep;86(1):287-95. doi: 10.1111/j.1476-5381.1985.tb09460.x.

DOI:10.1111/j.1476-5381.1985.tb09460.x
PMID:4052728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1916868/
Abstract

Treatment of rats with reserpine (1 mg kg-1 day-1) for up to 7 days resulted in a marked decrease in a corticosterone-sensitive component of the extraneuronal accumulation of [3H]-isoprenaline into their atria. The change in extraneuronal uptake did not appear to be due to a direct action of reserpine on the uptake mechanism, since it was several days before the treatment had a significant effect on the accumulation of [3H]-isoprenaline. Further, reserpine in vitro did not inhibit extraneuronal uptake. The reserpine-induced change in the accumulation of [3H]-isoprenaline was not an artifact due to changes in water balance, ion distribution, extracellular space or tissue atrophy. Nor was the change due to an increase in the efflux of [3H]-isoprenaline from the tissue. These experiments support the suggestion that the extraneuronal uptake is dependent upon a functional adrenergic innervation.

摘要

用利血平（1毫克/千克/天）对大鼠进行长达7天的处理，导致其心房中外神经元对[3H] - 异丙肾上腺素积累的皮质酮敏感成分显著减少。外神经元摄取的变化似乎不是由于利血平对摄取机制的直接作用，因为在处理数天后才对[3H] - 异丙肾上腺素的积累产生显著影响。此外，体外利血平并不抑制外神经元摄取。利血平诱导的[3H] - 异丙肾上腺素积累变化不是由于水平衡、离子分布、细胞外空间或组织萎缩的变化所导致的假象。该变化也不是由于[3H] - 异丙肾上腺素从组织中的流出增加所致。这些实验支持了外神经元摄取依赖于功能性肾上腺素能神经支配的观点。