N-亚硝基-N-甲基对甲苯磺酰胺在大鼠和人胃液中的转亚硝化活性。
Transnitrosating activity of N-nitroso-N-methyl-p-toluenesulfonamide in rats and human gastric juice.
作者信息
Börzsönyi M, Sajgó K, Török G, Pintér A, Tamás J, Kolar G, Spiegelhalder B
机构信息
National Institute of Hygiene, Budapest, Hungary.
出版信息
Neoplasma. 1988;35(3):257-62.
N-nitroso-N-methyl-p-toluenesulfonamide (NMTS, diazald, CAS 80-11-5) is a widely used compound for laboratory production of diazomethane. The present results showed that the noncarcinogenic NMTS reacts as a transnitrosating agent with amino nitrogen of secondary amines and amide both in vitro (human gastric juice) and in vivo (rats) to yield N-nitroso compounds. Since all compounds formed (NMOR, NDMA, NPIP, NPZ, NMU) are known animal carcinogens, caution should be taken by users handling NMTS.
N-亚硝基-N-甲基对甲苯磺酰胺（NMTS，重氮醛，CAS 80-11-5）是一种广泛用于实验室制备重氮甲烷的化合物。目前的结果表明，非致癌性的NMTS在体外（人胃液）和体内（大鼠）均作为亚硝化剂与仲胺和酰胺的氨基氮反应，生成N-亚硝基化合物。由于所有生成的化合物（NMOR、NDMA、NPIP、NPZ、NMU）都是已知的动物致癌物，处理NMTS的使用者应谨慎。
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