Zhang Lili, Zhang Junhu, Hu Ming, Feng Xungang
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining 272029, Shandong, China. Corresponding author: Feng Xungang, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2021 Apr;33(4):491-493. doi: 10.3760/cma.j.cn121430-20201110-00709.
Rickettsia felis is a Gram-negative prokaryotic organism that is obligatorically parasitic in cells. Cat fleas are the main vector of Rickettsia felis. Clinical symptoms of human infection with Rickettsia felis include fever, fatigue, headache, macular papules, and eschar. There are few reports of serious complications or deaths due to infection of Rickettsia felis. A confirmed case of severe encephalitis caused by Rickettsia felis infection was admitted to neurology department of Affiliated Hospital of Jining Medical University on January 29, 2020. After comprehensive treatment of antiviral by acyclovir, mannitol dehydration to reduce intracranial pressure, human immunoglobulin to regulateimmunity, minocycline hydrochloride capsule, levofloxacin mesylate and sodium chloride against Rickettsia felis infection, control of seizure and pulmonary infection, the patient's condition was improved and then discharged. By summarizing the experience and lessons in the treatment of this patient, we hope to remind everyone to strengthen the understanding of Rickettsia felis infection.
猫立克次体是一种革兰氏阴性原核生物，专性寄生于细胞内。猫蚤是猫立克次体的主要传播媒介。人类感染猫立克次体的临床症状包括发热、乏力、头痛、斑丘疹和焦痂。因猫立克次体感染导致严重并发症或死亡的报道较少。2020年1月29日，济宁医学院附属医院神经内科收治了1例确诊为由猫立克次体感染引起的重症脑炎患者。经过阿昔洛韦抗病毒、甘露醇脱水降颅压、人免疫球蛋白调节免疫、盐酸米诺环素胶囊、甲磺酸左氧氟沙星及氯化钠抗猫立克次体感染、控制癫痫及肺部感染等综合治疗后，患者病情好转并出院。通过总结该患者的治疗经验教训，希望提醒大家加强对猫立克次体感染的认识。
