Leibenluft Ellen, Kircanski Katharina
Section on Mood Dysregulation and Neuroscience, Intramural Research Program, National Institute of Mental Health, Building 15K, MSC 2670, Bethesda, MD 20892-2670, USA.
Section on Mood Dysregulation and Neuroscience, Intramural Research Program, National Institute of Mental Health, Building 15K, MSC 2670, Bethesda, MD 20892-2670, USA.
Child Adolesc Psychiatr Clin N Am. 2021 Jul;30(3):667-683. doi: 10.1016/j.chc.2021.04.014.
This commentary focuses on irritability, one subtype of emotion dysregulation. We review literature demonstrating that irritability is not a developmental phenotype of bipolar disorder, but is longitudinally associated with unipolar depression and anxiety and genetically associated with unipolar depression, anxiety, and attention-deficit hyperactivity disorder. We describe how irritability is amenable to translational research, in part because of the relevance of frustrative nonreward, a model developed in rodents, to human irritability. Last, we demonstrate how such research has suggested a novel exposure-based intervention for irritability.
本评论聚焦于易激惹性，这是情绪失调的一种亚型。我们回顾了相关文献，这些文献表明易激惹性并非双相情感障碍的一种发育表型，而是与单相抑郁和焦虑存在纵向关联，并且在基因上与单相抑郁、焦虑以及注意力缺陷多动障碍相关。我们描述了易激惹性如何适用于转化研究，部分原因在于啮齿动物模型中所发展出的挫折性无奖赏与人类易激惹性的相关性。最后，我们展示了此类研究如何提出了一种针对易激惹性的基于暴露的新型干预措施。
