King Hussein Cancer Center, Queen Rania Al-Abdallah Street, PO Box 1269, Amman 11941, Jordan.
University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Crit Care Clin. 2021 Jul;37(3):625-641. doi: 10.1016/j.ccc.2021.03.008.
Drug-induced iatrogenic toxicities are common in critically ill patients and have been associated with increased morbidity and mortality. Early recognition and management of iatrogenic toxicities is essential; however, the diagnosis is usually complicated by the underlying critical illness, comorbidities, and administration of multiple medications. This article reviews several types of iatrogenic toxicities associated with medications that are commonly used in critically ill patients. The mechanism of the iatrogenic toxicities, clinical presentation, and diagnosis, as well as management are discussed.
药物性医源性毒性在危重症患者中很常见，并与发病率和死亡率的增加有关。早期识别和管理医源性毒性至关重要；然而，由于潜在的危重病、合并症和多种药物的使用，诊断通常很复杂。本文综述了与危重症患者常用药物相关的几种医源性毒性。讨论了医源性毒性的发病机制、临床表现和诊断以及治疗。
