在重症监护病房中，罕见药物反应的常见表现和常见药物反应的非典型表现。

Common Presentations of Rare Drug Reactions and Atypical Presentations of Common Drug Reactions in the Intensive Care Unit.

机构信息

Department of Anesthesiology, Section of Pediatric Anesthesiology, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53122, USA; Department of Pediatrics, Section of Pediatric Critical Care, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53122, USA.

出版信息

Crit Care Clin. 2022 Apr;38(2):287-299. doi: 10.1016/j.ccc.2021.11.005.

DOI:10.1016/j.ccc.2021.11.005

PMID:35369948

Abstract

Adverse drug events (ADRs) are a significant source of iatrogenic injury that may be challenging to diagnose and treat. Patient outcomes range from mild symptoms to death. Critically ill children are at unique risk for ADR development because of age-dependent pharmacokinetic differences and off-label prescribing.

摘要

药物不良反应（ADR）是医源性损伤的一个重要来源，可能难以诊断和治疗。患者的结局从轻微症状到死亡不等。由于年龄相关的药代动力学差异和超说明书用药，危重症儿童发生药物不良反应的风险独特。