Department of Anesthesiology, Section of Pediatric Anesthesiology, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53122, USA; Department of Pediatrics, Section of Pediatric Critical Care, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53122, USA.
Department of Anesthesiology, Section of Pediatric Anesthesiology, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53122, USA; Department of Pediatrics, Section of Pediatric Critical Care, Medical College of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53122, USA.
Crit Care Clin. 2022 Apr;38(2):287-299. doi: 10.1016/j.ccc.2021.11.005.
Adverse drug events (ADRs) are a significant source of iatrogenic injury that may be challenging to diagnose and treat. Patient outcomes range from mild symptoms to death. Critically ill children are at unique risk for ADR development because of age-dependent pharmacokinetic differences and off-label prescribing.
药物不良反应（ADR）是医源性损伤的一个重要来源，可能难以诊断和治疗。患者的结局从轻微症状到死亡不等。由于年龄相关的药代动力学差异和超说明书用药，危重症儿童发生药物不良反应的风险独特。
