超声辅助由1,4-萘醌和α-氨基缩醛一锅法合成苯并稠合吲哚-4,9-二酮
Ultrasound assisted one-pot synthesis of benzo-fused indole-4, 9-dinones from 1,4-naphthoquinone and α-aminoacetals.
作者信息
Luu Quang H, Guerra Jorge D, Castañeda Cecilio M, Martinez Manuel A, Saunders Jong, Garcia Benjamin A, Gonzales Brenda V, Aidunuthula Anushritha R, Mito Shizue
机构信息
Department of Chemistry, The University of Texas at El Paso, El Paso, TX 79968, USA.
Department of Chemistry, The University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.
出版信息
Tetrahedron Lett. 2016 May 25;57(21):2253-2256. doi: 10.1016/j.tetlet.2016.04.031. Epub 2016 Apr 16.
Abstract
A one-pot synthesis of benzo[]indole-4,9-diones from 1,4-naphthoquinone with α-aminoacetals has been developed. This method provides a straightforward synthesis of benzo[]indole-4,9-diones via intramolecular nucleophilic attack of aminoquinones to aldehydes under mild reaction conditions. The detailed mechanism was also investigated.
摘要
已开发出一种由1,4-萘醌与α-氨基缩醛一锅法合成苯并[ ]吲哚-4,9-二酮的方法。该方法通过氨基醌对醛的分子内亲核进攻，在温和的反应条件下直接合成苯并[ ]吲哚-4,9-二酮。还对详细的反应机理进行了研究。
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