Department of Burns, The Fifth Hospital of Harbin, Harbin, China.
Orthopaedic Ward, The Fifth Hospital of Harbin, Harbin, China.
J Dermatolog Treat. 2022 Feb;33(1):131-137. doi: 10.1080/09546634.2020.1729949. Epub 2020 Feb 21.
To evaluate the efficacy of platelet-rich plasma (PRP) in the treatment of burn wounds.
A comprehensive literature survey was conducted in electronic medical journal databases to identify studies that examined the effect of PRP treatment to burn wounds and meta-analyses of mean differences (MD) standardized MD, or odds ratios were performed.
The percentage of graft take was not significantly different between PRP-treated and control wound areas. Healing rate was significantly better in PRP-treated wounds. Healing time was also significantly less in PRP-treated wounds. There was no significant difference between PRP-treated and control wound areas in epithelialization or in the incidence of adverse events. Incidence of infection was also not different between PRP-treated and control wound areas. Scar assessment score was significantly better in PRP-treated than in control wound areas.
PRP treatment to burn wounds is found to improve healing. Variations in study design and sample size, types of wounds, PRP preparation protocols, and high risk of bias in some of the included studies may have impact on these outcomes.
评估富血小板血浆（PRP）治疗烧伤创面的疗效。
对电子医学期刊数据库进行全面文献检索，以确定研究 PRP 治疗烧伤创面的效果，并进行平均差（MD）标准化 MD 或比值比的荟萃分析。
PRP 治疗区与对照组创面的植皮成活率无显著差异。PRP 治疗组创面的愈合率明显更好。PRP 治疗组创面的愈合时间也明显缩短。PRP 治疗组与对照组创面在上皮化或不良事件发生率方面无显著差异。PRP 治疗组与对照组创面的感染发生率也无差异。PRP 治疗组创面的瘢痕评估评分明显优于对照组。
PRP 治疗烧伤创面可促进愈合。但研究设计和样本量、创面类型、PRP 制备方案的差异，以及部分纳入研究的偏倚风险较高，可能对这些结果产生影响。
