精雕细琢：铁如何调控巨噬细胞极化。
Ironing Out the Details: How Iron Orchestrates Macrophage Polarization.
机构信息
State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat Quality and Safety Control and Evaluation, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, China.
College of Animal Science, South China Agricultural University, Guangzhou, China.
出版信息
Front Immunol. 2021 May 12;12:669566. doi: 10.3389/fimmu.2021.669566. eCollection 2021.
Iron fine-tunes innate immune responses, including macrophage inflammation. In this review, we summarize the current understanding about the iron in dictating macrophage polarization. Mechanistically, iron orchestrates macrophage polarization through several aspects, including cellular signaling, cellular metabolism, and epigenetic regulation. Therefore, iron modulates the development and progression of multiple macrophage-associated diseases, such as cancer, atherosclerosis, and liver diseases. Collectively, this review highlights the crucial role of iron for macrophage polarization, and indicates the potential application of iron supplementation as an adjuvant therapy in different inflammatory disorders relative to the balance of macrophage polarization.
铁微调先天免疫反应，包括巨噬细胞炎症。在这篇综述中，我们总结了目前关于铁决定巨噬细胞极化的理解。从机制上讲，铁通过几个方面来协调巨噬细胞极化，包括细胞信号转导、细胞代谢和表观遗传调控。因此，铁调节多种与巨噬细胞相关的疾病的发展和进展，如癌症、动脉粥样硬化和肝脏疾病。总的来说，这篇综述强调了铁对巨噬细胞极化的关键作用，并表明了在不同的炎症性疾病中补充铁作为辅助治疗相对于巨噬细胞极化平衡的潜在应用。
Zotero 插件