Talebnejad Mohammad Reza, Azimi Ali, Khalili Mohammad Reza, Meshksar Aidin
Poostchi Ophthalmology Research Center, Department of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran.
J Ophthalmic Vis Res. 2021 Apr 29;16(2):165-170. doi: 10.18502/jovr.v16i2.9079. eCollection 2021 Apr-Jun.
Pseudoexfoliation syndrome (PXF) is an age-related condition, characterized by deposition of whitish flake-shaped materials in the anterior segment of the eye. Although it occurs all over the world, a considerable racial variation exists. According to the high frequency of PXF in Iran and the importance of prevention and early treatment, we evaluated the plasma level of iron, zinc, copper, and magnesium in patients with PXF.
In this study, 83 individuals were enrolled; 40 patients with cataract and PXF as the case group and 43 age- and sex-matched individuals with cataract but without PXF as the control group. The serum levels of the mentioned microelements were compared in two groups.
In the case group, 25 (62.5%) male and 15 (37.5%) female subjects participated. In the control group, the corresponding figures were 22 (51.2%) and 21 (48.8%), respectively. The mean age of the case group was 66.07 9.46 and that for the control group was 66.88 8.04 years. Regarding the case group, the serum levels of iron, zinc, copper, and magnesium were 60.58 21.04, 84.7 14.37, 120.23 14.43, and 2.11 0.23, respectively. These serum levels in the control group were 89.07 26.06, 97.51 17.42, 123.33 19.01, and 2.14 0.16. The serum levels of iron and zinc were significantly lower in the case group than the control group ( 0.0001); however, such a difference was not observed in terms of copper and magnesium serum levels.
Our study demonstrated that the serum iron and zinc levels were lower in PXF patients. Nutritional deficiency may be a cause of zonular weakness in these patients. is a cofactor for the enzyme which contributes to the biosynthesis of fibrillin, the major protein in zonular fibers. Therefore, iron can play a substantial role in the biosynthesis of the fibrils and also in the zonular stability.
假性剥脱综合征（PXF）是一种与年龄相关的病症，其特征为在眼前节出现白色片状物质沉积。尽管该病症在全球范围内均有发生，但存在相当大的种族差异。鉴于伊朗PXF的高发病率以及预防和早期治疗的重要性，我们评估了PXF患者血浆中铁、锌、铜和镁的水平。
本研究纳入了83名个体；40例患有白内障和PXF的患者作为病例组，43例年龄和性别匹配的患有白内障但无PXF的个体作为对照组。比较了两组中上述微量元素的血清水平。
病例组中，男性受试者25名（62.5%），女性受试者15名（37.5%）。对照组中，相应数字分别为22名（51.2%）和21名（48.8%）。病例组的平均年龄为66.07±9.46岁，对照组为66.88±8.04岁。病例组中铁、锌、铜和镁的血清水平分别为60.58±21.04、84.7±14.37、120.23±14.43和2.11±0.23。对照组中这些血清水平分别为89.07±26.06、97.51±17.42、123.33±19.01和2.14±0.16。病例组中铁和锌的血清水平显著低于对照组（P<0.0001）；然而，在铜和镁的血清水平方面未观察到此类差异。
我们的研究表明，PXF患者的血清铁和锌水平较低。营养缺乏可能是这些患者悬韧带薄弱的一个原因。铁是一种酶的辅助因子，该酶有助于原纤维蛋白的生物合成，原纤维蛋白是悬韧带纤维中的主要蛋白质。因此，铁在纤维的生物合成以及悬韧带稳定性方面可发挥重要作用。
