前哨淋巴结手术在儿科肢体横纹肌肉瘤中的应用：系统评价和回顾性队列研究。
Value of the Sentinel Node Procedure in Pediatric Extremity Rhabdomyosarcoma: A Systematic Review and Retrospective Cohort Study.
机构信息
Pediatric Surgery, Pediatric Solid Tumor Unit, Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Trial and Data Center, Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.
出版信息
Ann Surg Oncol. 2021 Dec;28(13):9048-9059. doi: 10.1245/s10434-021-10035-9. Epub 2021 May 31.
BACKGROUND
Our aim is to show whether the sentinel node procedure (SNP) is recommendable for pediatric patients with extremity rhabdomyosarcoma (RMS). Lymph node metastases are an important prognostic factor in pediatric patients with extremity RMS. Accurate nodal staging is necessary to treat the patient accordingly. An alternative to the current recommended lymph node sampling is the sentinel node procedure (SNP).
METHODS
A systematic review was performed summarizing all published cases of SNP in addition to 13 cases from our hospital and 8 cases from two other hospitals that have not been published before.
RESULTS
For all patients (n = 55), at least one SLN was identified, but the SNP technique used was not uniform. The SNP changed the nodal classification of eight patients (17.0%) and had a false-negative rate of 10.5%.
CONCLUSIONS
The SNP is recommendable for pediatric patients with extremity RMS. It can change lymph node status and can be used to sample patients in a more targeted way than nodal sampling alone. Therefore, we recommend use of the SNP in addition to clinical and radiological nodal assessment for pediatric patients with extremity RMS.
背景
我们旨在探讨前哨淋巴结活检术（SNP）是否适用于四肢横纹肌肉瘤（RMS）的儿科患者。淋巴结转移是四肢 RMS 儿科患者的一个重要预后因素。准确的淋巴结分期对于患者的治疗至关重要。目前推荐的淋巴结取样方法有替代方法，即前哨淋巴结活检术（SNP）。
方法
系统综述总结了所有已发表的 SNP 病例，以及我们医院的 13 例和另外两家尚未发表的医院的 8 例病例。
结果
对于所有患者（n=55），至少有一个 SLN 被识别，但使用的 SNP 技术并不统一。SNP 改变了 8 例患者（17.0%）的淋巴结分类，假阴性率为 10.5%。
结论
SNP 适用于四肢 RMS 的儿科患者。它可以改变淋巴结状态，并且可以比单独的淋巴结取样更有针对性地对患者进行取样。因此，我们建议在四肢 RMS 儿科患者的临床和影像学淋巴结评估之外，使用 SNP。
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