Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Division of Pediatric Gastroenterology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Clin Gastroenterol Hepatol. 2022 Apr;20(4):e664-e670. doi: 10.1016/j.cgh.2021.05.044. Epub 2021 May 28.
BACKGROUND & AIMS: The prevalence of psychiatric comorbidity in nonesophageal eosinophilic gastrointestinal disorders (EGIDs) has not been studied. We aimed to ascertain the prevalence of psychiatric diagnoses and psychiatric medication use in children, adolescents, and adults with EGIDs and to assess whether psychiatric comorbidity affects clinical presentation.
This was a retrospective cohort study of newly diagnosed patients with a nonesophageal EGID at the University of North Carolina from 2008 to 2020. Psychiatric diagnoses and medications were extracted from medical records. We compared the clinical and demographic features of EGID patients with and without psychiatric diagnoses.
Of 79 patients (mean 23.3 years of age, 53% male, 78% White) with a nonesophageal EGID diagnosis, 40 (51%) were diagnosed with a comorbid psychiatric disease. Anxiety (37%) and depression (28%) were most common. There were also 40 (51%) patients treated medically for a psychiatric diagnosis. Patients with a psychiatric diagnosis were more commonly ≥18 years of age at the time of EGID diagnosis (odds ratio [OR], 3.95, 95% confidence interval [CI], 1.20-13.02) and had endorsed symptoms of nausea (OR, 5.31; 95% CI, 1.33-21.22) and dysphagia (OR, 4.24; 95% CI, 1.18-15.26).
Psychiatric diagnoses were very common in nonesophageal EGID patients with approximately 7 in 10 adults and one-third of children diagnosed. Similar proportions were found for psychiatric medication use. We also found that psychiatric illness may influence age of clinical presentation and symptoms. Providers should assess for concomitant psychiatric comorbidities in EGID patients.
非食管嗜酸性粒细胞性胃肠道疾病（EGID）患者的精神共病患病率尚未得到研究。我们旨在确定 EGID 患儿、青少年和成人的精神科诊断和精神科药物使用情况，并评估精神共病是否影响临床表现。
这是一项回顾性队列研究，纳入了 2008 年至 2020 年期间在北卡罗来纳大学诊断为非食管 EGID 的新患者。从病历中提取精神科诊断和药物信息。我们比较了 EGID 患者有无精神科诊断的临床和人口统计学特征。
在 79 例非食管 EGID 患者中（平均年龄 23.3 岁，53%为男性，78%为白人），40 例（51%）患者被诊断为合并精神疾病。焦虑症（37%）和抑郁症（28%）最为常见。还有 40 例（51%）患者因精神科诊断接受药物治疗。有精神科诊断的患者 EGID 诊断时年龄≥18 岁的比例更高（比值比 [OR]，3.95，95%置信区间 [CI]，1.20-13.02），且有恶心（OR，5.31；95% CI，1.33-21.22）和吞咽困难（OR，4.24；95% CI，1.18-15.26）症状。
非食管 EGID 患者的精神科诊断非常常见，约 10 个成年人中有 7 个，30%的儿童被诊断为精神疾病。精神科药物使用的比例也相似。我们还发现，精神疾病可能会影响临床表现的年龄和症状。在 EGID 患者中，医生应评估是否存在并存的精神共病。
