Timilsina Sujan, Joshi Surya Prakash, Sharma Sujan, Kharel Sanjeev, Karki Shovana, Tiwari Sansar Babu, Pandit Durga, Parajuli Purushottam
Maharajgunj Medical Campus, Institute of Medicine, Kathmandu, Nepal.
Department of Pathology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
Int J Surg Case Rep. 2021 Jun;83:106018. doi: 10.1016/j.ijscr.2021.106018. Epub 2021 May 26.
Adrenal schwannomas are extremely rare tumors often misdiagnosed. The patients are usually asymptomatic while some present with non-specific abdominal pain. Only a few cases are reported to date.
We here present a case of a 55-year-old Nepalese man presented with nonspecific abdominal pain at our Outpatient Department (OPD) found to have mass on ultrasonography of abdomen. On further investigation with Contrast Enhanced Computerized Tomography (CECT) of the abdomen and pelvis, a well-defined heterogeneous adrenal mass of size (7.8 ∗ 8.3 ∗ 6) cm with foci of calcification was seen in the left retroperitoneum. The intraoperative finding of adrenal mass and histopathology of resected mass was suggestive of schwannoma arising from the adrenal gland which was further confirmed by immunohistochemistry.
Adrenal schwannoma can mimic tumors like pheochromocytoma, adrenal adenoma, cortical carcinoma, neuroblastoma, and other masses. Only 1-3% of schwannomas are retroperitoneal. Radiological findings of this tumor are non-suggestive. The histological section shows spindle cells with Antoni A and Antoni B regions while positive staining of S-100 protein in Immunohistochemistry.
The diagnosis of adrenal schwannoma in the retroperitoneum is often challenging. The treatment of choice is surgical resection with a good prognosis.
肾上腺神经鞘瘤极为罕见,常被误诊。患者通常无症状,部分患者表现为非特异性腹痛。迄今为止,仅有少数病例报道。
我们在此呈现一例55岁尼泊尔男性患者,其在我院门诊因非特异性腹痛就诊,腹部超声检查发现有肿块。进一步行腹部及盆腔增强计算机断层扫描(CECT)检查,在左腹膜后发现一个边界清晰的大小为(7.8×8.3×6)cm的异质性肾上腺肿块,伴有钙化灶。术中发现肾上腺肿块,切除肿块的组织病理学检查提示为肾上腺来源的神经鞘瘤,免疫组化进一步证实。
肾上腺神经鞘瘤可类似嗜铬细胞瘤、肾上腺腺瘤、皮质癌、神经母细胞瘤及其他肿块。仅1% - 3%的神经鞘瘤位于腹膜后。该肿瘤的影像学表现无特异性。组织学切片显示梭形细胞,有Antoni A区和Antoni B区,免疫组化中S - 100蛋白呈阳性染色。
腹膜后肾上腺神经鞘瘤的诊断往往具有挑战性。治疗的首选方法是手术切除,预后良好。