Department of Pathology and Laboratory Medicine, Brody School of Medicine at East Carolina University, Greenville, North Carolina 27858-4353, USA.
Arch Pathol Lab Med. 2013 Jul;137(7):1009-14. doi: 10.5858/arpa.2012-0291-RS.
Adrenal schwannoma is a rare type of adrenal incidentaloma, an adrenal lesion found incidentally, usually on imaging or autopsy. Computed tomography and magnetic resonance imaging are tools used to evaluate adrenal lesions. The diagnosis of adrenal schwannoma, however, cannot be made on imaging alone. Surgical resection is the primary means of management of adrenal schwannomas, as it is not possible to distinguish the schwannoma from malignant entities simply based on imaging. Histopathologic features of adrenal schwannomas are similar to those of schwannomas found at other sites. Conventional schwannomas, consisting of alternating Antoni A and Antoni B areas as well as Verocay bodies, have distinct microscopic features and can be readily distinguished from other entities. Cellular schwannomas, on the other hand, consist only of intersecting fascicles of spindle cells or Antoni A areas, resulting in a wide differential diagnosis. Ancillary studies such as immunohistochemical analysis and electron microscopy can help to provide a specific diagnosis.
肾上腺神经鞘瘤是一种罕见的肾上腺偶发瘤，即偶然发现的肾上腺病变，通常在影像学检查或尸检中发现。计算机断层扫描（CT）和磁共振成像（MRI）是用于评估肾上腺病变的工具。然而，仅凭影像学检查无法确诊肾上腺神经鞘瘤。手术切除是肾上腺神经鞘瘤的主要治疗方法，因为仅凭影像学检查无法将神经鞘瘤与恶性肿瘤区分开来。肾上腺神经鞘瘤的组织病理学特征与其他部位的神经鞘瘤相似。传统的神经鞘瘤由交替的 Antoni A 和 Antoni B 区域以及 Verocay 小体组成，具有独特的显微镜特征，易于与其他实体区分开来。细胞性神经鞘瘤则仅由交叉的梭形细胞束或 Antoni A 区域组成，导致广泛的鉴别诊断。辅助研究，如免疫组织化学分析和电子显微镜检查，可以帮助提供明确的诊断。
