Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA; Oakland University William Beaumont School of Medicine, 586 Pioneer Drive, Rochester, MI 48309-4482, USA.
Connective Tissue Disease Clinic, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA.
Med Clin North Am. 2021 Jul;105(4):757-782. doi: 10.1016/j.mcna.2021.04.011.
Connective tissue diseases (CTDs) encompass a broad spectrum of clinical presentations that involve multidisciplinary management. Cutaneous findings are common in CTD and careful examination of these features aids in appropriate diagnosis and subsequent evaluation. Thorough work-up of CTD is crucial to properly identify disease subtypes and systemic involvement. Management plans can be developed based on diagnosis and systemic manifestations of disease. Disease management often requires treatment with pharmacotherapies with potential for toxicities, further underscoring the importance of diagnostic accuracy in this patient population. Evolving research strives to better elucidate the pathogenic mechanisms of CTDs allowing for more targeted treatment modalities.
结缔组织病（CTD）包括广泛的临床表现，涉及多学科管理。皮肤表现常见于 CTD，仔细检查这些特征有助于做出适当的诊断和随后的评估。对 CTD 进行彻底的检查对于正确识别疾病亚型和全身受累至关重要。管理计划可以根据诊断和疾病的全身表现来制定。疾病管理通常需要使用可能有毒性的药物治疗，这进一步强调了在这一患者群体中诊断准确性的重要性。不断发展的研究努力更好地阐明 CTD 的发病机制，从而为更有针对性的治疗方式提供了可能。
