Wester Roland
Institut für Ionenphysik und Angewandte Physik, Universität Innsbruck, Technikerstraße 25, 6020, Innsbruck, Austria.
Mass Spectrom Rev. 2021 May 31;41(4):627-44. doi: 10.1002/mas.21705.
Bimolecular nucleophilic substitution ( ) reactions have become a model system for the investigation of structure-reactivity relationships, stereochemistry, solvent influences, and detailed atomistic dynamics. In this review, the progress during five decades of experimental and theoretical research on gas phase reactions is discussed. Many advancements of the employed methods have led to a tremendous increase in our understanding of the properties and the dynamics of these reactions. For reactions involving six atoms a quantitative agreement of the differential reactive scattering cross sections has already been achieved, in the future it is expected that even larger polyatomic reactions systems become tractable. Furthermore, studies with higher precision, improved reactant control, and a more accurate theoretical treatment of quantum effects are envisioned.
双分子亲核取代（ ）反应已成为研究结构-反应性关系、立体化学、溶剂影响以及详细原子动力学的模型体系。在本综述中，将讨论气相 反应五十年来实验和理论研究的进展。所采用方法的许多进步极大地增进了我们对这些反应性质和动力学的理解。对于涉及六个原子的反应，已经实现了微分反应散射截面的定量一致性，预计未来甚至更大的多原子反应体系也将变得易于处理。此外，还设想了具有更高精度、改进反应物控制以及对量子效应进行更精确理论处理的研究。
