Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA; email:
Annu Rev Vis Sci. 2021 Sep 15;7:633-664. doi: 10.1146/annurev-vision-100419-114940. Epub 2021 Jun 1.
Multifaceted and divergent manifestations across tissues and cell types have curtailed advances in deciphering the cellular events that accompany advanced age and contribute to morbidities and mortalities. Increase in human lifespan during the past century has heightened awareness of the need to prevent age-associated frailty of neuronal and sensory systems to allow a healthy and productive life. In this review, we discuss molecular and physiological attributes of aging of the retina, with a goal of understanding age-related impairment of visual function. We highlight the epigenome-metabolism nexus and proteostasis as key contributors to retinal aging and discuss lifestyle changes as potential modulators of retinal function. Finally, we deliberate promising intervention strategies for promoting healthy aging of the retina for improved vision.
多方面和多样化的组织和细胞类型的表现，阻碍了对伴随衰老的细胞事件的破译，这些事件导致了发病率和死亡率的增加。在过去的一个世纪中，人类寿命的延长提高了人们对预防与年龄相关的神经元和感觉系统衰弱的认识，以实现健康和富有成效的生活。在这篇综述中，我们讨论了视网膜衰老的分子和生理特征，旨在了解与年龄相关的视觉功能障碍。我们强调了表观基因组-代谢关联和蛋白质稳态作为导致视网膜衰老的关键因素，并讨论了生活方式的改变作为视网膜功能的潜在调节剂。最后，我们审议了促进视网膜健康衰老以改善视力的有前途的干预策略。
