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加拿大安大略省阿片类药物使用者获得初级保健服务的不平等:基于人群的队列研究。

Inequities in access to primary care among opioid recipients in Ontario, Canada: A population-based cohort study.

机构信息

Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Canada.

ICES, Toronto, Canada.

出版信息

PLoS Med. 2021 Jun 1;18(6):e1003631. doi: 10.1371/journal.pmed.1003631. eCollection 2021 Jun.

Abstract

BACKGROUND

Stigma and high-care needs can present barriers to the provision of high-quality primary care for people with opioid use disorder (OUD) and those prescribed opioids for chronic pain. We explored the likelihood of securing a new primary care provider (PCP) among people with varying histories of opioid use who had recently lost access to their PCP.

METHODS AND FINDINGS

We conducted a retrospective cohort study using linked administrative data among residents of Ontario, Canada whose enrolment with a physician practicing in a primary care enrolment model (PEM) was terminated between January 2016 and December 2017. We assigned individuals to 3 groups based upon their opioid use on the date enrolment ended: long-term opioid pain therapy (OPT), opioid agonist therapy (OAT), or no opioid. We fit multivariable models assessing the primary outcome of primary care reattachment within 1 year, adjusting for demographic characteristics, clinical comorbidities, and health services utilization. Secondary outcomes included rates of emergency department (ED) visits and opioid toxicity events. Among 154,970 Ontarians who lost their PCP, 1,727 (1.1%) were OAT recipients, 3,644 (2.4%) were receiving long-term OPT, and 149,599 (96.5%) had no recent prescription opioid exposure. In general, OAT recipients were younger (median age 36) than those receiving long-term OPT (59 years) and those with no recent prescription opioid exposure (44 years). In all exposure groups, the majority of individuals had their enrolment terminated by their physician (range 78.1% to 88.8%). In the primary analysis, as compared to those not receiving opioids, OAT recipients were significantly less likely to find a PCP within 1 year (adjusted hazard ratio [aHR] 0.55, 95% confidence interval [CI] 0.50 to 0.61, p < 0.0001). We observed no significant difference between long-term OPT and opioid unexposed individuals (aHR 0.96; 95% CI 0.92 to 1.01, p = 0.12). In our secondary analysis comparing the period of PCP loss to the year prior, we found that rates of ED visits were elevated among people not receiving opioids (adjusted rate ratio (aRR) 1.20, 95% CI 1.18 to 1.22, p < 0.0001) and people receiving long-term OPT (aRR 1.37, 95% CI 1.28 to 1.48, p < 0.0001). We found no such increase among OAT recipients, and no significant increase in opioid toxicity events in the period following provider loss for any exposure group. The main limitation of our findings relates to their generalizability outside of PEMs and in jurisdictions with different financial incentives incorporated into primary care provision.

CONCLUSIONS

In this study, we observed gaps in access to primary care among people who receive prescription opioids, particularly among OAT recipients. Ongoing efforts are needed to address the stigma, discrimination, and financial disincentives that may introduce barriers to the healthcare system, and to facilitate access to high-quality, consistent primary care services for chronic pain patients and those with OUD.

摘要

背景

耻辱感和高护理需求可能会成为为患有阿片类药物使用障碍(OUD)和因慢性疼痛而开阿片类药物的人提供高质量初级保健的障碍。我们探讨了在最近失去初级保健提供者(PCP)的不同阿片类药物使用史的人群中获得新 PCP 的可能性。

方法和发现

我们使用加拿大安大略省的链接行政数据进行了一项回顾性队列研究,该研究的参与者是在 2016 年 1 月至 2017 年 12 月期间与从事初级保健注册模式(PEM)的医生注册终止的患者。我们根据注册结束日期的阿片类药物使用情况将个人分为 3 组:长期阿片类药物疼痛治疗(OPT)、阿片类药物激动剂治疗(OAT)或无阿片类药物。我们使用多变量模型评估了在 1 年内重新获得初级保健的主要结果,调整了人口统计学特征、临床合并症和卫生服务利用情况。次要结果包括急诊部(ED)就诊率和阿片类药物毒性事件发生率。在失去 PCP 的 154970 名安大略人中,有 1727 名(1.1%)是 OAT 接受者,3644 名(2.4%)正在接受长期 OPT,149599 名(96.5%)最近没有处方阿片类药物暴露。一般来说,OAT 接受者比接受长期 OPT(59 岁)和最近没有处方阿片类药物暴露(44 岁)的人更年轻(中位数年龄 36 岁)。在所有暴露组中,大多数人(范围为 78.1%至 88.8%)是由他们的医生终止注册的。在主要分析中,与未接受阿片类药物的人相比,OAT 接受者在 1 年内找到 PCP 的可能性显著降低(调整后的危险比 [aHR] 0.55,95%置信区间 [CI] 0.50 至 0.61,p < 0.0001)。我们没有发现长期 OPT 和未接受阿片类药物的个体之间存在显著差异(aHR 0.96;95%CI 0.92 至 1.01,p = 0.12)。在我们比较 PCP 丢失期和前一年的次要分析中,我们发现未接受阿片类药物的人(调整后的比率比 [aRR] 1.20,95%CI 1.18 至 1.22,p < 0.0001)和接受长期 OPT 的人(aRR 1.37,95%CI 1.28 至 1.48,p < 0.0001)急诊就诊率升高。我们没有发现 OAT 接受者有这种增加,也没有发现任何暴露组在提供者丧失后的时期内阿片类药物毒性事件的显著增加。我们研究结果的主要限制是它们在 PEM 之外和在纳入不同经济激励措施的初级保健提供的司法管辖区内的推广性。

结论

在这项研究中,我们观察到接受处方阿片类药物的人获得初级保健的机会存在差距,特别是在 OAT 接受者中。需要继续努力解决耻辱感、歧视和经济激励措施带来的障碍,为慢性疼痛患者和患有 OUD 的人提供高质量、一致的初级保健服务。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c47/8168863/2ae0ff25d615/pmed.1003631.g001.jpg

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