技术说明：基于低成本、小型化微波发生器的紧凑型热声成像系统，用于活体生物医学成像。
Technical Note: Compact thermoacoustic imaging system based on a low-cost and miniaturized microwave generator for in vivo biomedical imaging.
机构信息
School of optoelectric Engineering, Chongqing University of Posts and Telecommunications, Chongqing, 400065, China.
School of Electronic Science and Engineering (National Exemplary School of Microelectronics), University of Electronic Science and Technology of China, Chengdu, 611731, China.
出版信息
Med Phys. 2021 Aug;48(8):4242-4248. doi: 10.1002/mp.15014. Epub 2021 Jun 30.
PURPOSE
Most of existing thermoacoustic imaging (TAI) studies generally utilized a linear modulator-based high peak power magnetron generator (MG) for efficient TA signal excitation. However, a linear modulator-based MG is bulky and expensive. Here we present a low-cost and compact thermoacoustic imaging (TAI) system based on a miniaturized MG.
METHODS
The MG is based on solid-state modulator and operates at 3.05 ± 0.025 GHz, with a peak power of up to 60 kW and adjustable pulse duration from 70 to 600 ns. The dimensions and weight of this MG are 350 × 210 × 70 mm (Width × Length × Height) and 7.5 kg, respectively.
RESULTS
The spatial resolution of the miniaturized MG-based TAI system is determined to be from 0.3 to 1.4 mm using controlled phantom experiments. The system is further evaluated using in vivo experiments where the finger joints and vasculature in the forearm and opisthenar of human participants are successfully imaged.
CONCLUSIONS
This study suggests that the miniaturized MG based TAI systems can be used for in vivo joint and vascular imaging with multiscale resolutions (0.3-1.4 mm).
目的
大多数现有的热声成像（TAI）研究通常采用基于线性调制器的高峰值功率磁控管发生器（MG）来有效激发 TA 信号。然而，基于线性调制器的 MG 体积庞大且昂贵。在这里，我们提出了一种基于小型化 MG 的低成本紧凑型热声成像（TAI）系统。
方法
MG 基于固态调制器，工作频率为 3.05±0.025GHz，峰值功率高达 60kW，脉冲持续时间可调从 70 到 600ns。该 MG 的尺寸和重量分别为 350×210×70mm（宽×长×高）和 7.5kg。
结果
通过受控的体模实验，确定了基于小型化 MG 的 TAI 系统的空间分辨率为 0.3 至 1.4mm。该系统进一步通过体内实验进行了评估，成功地对人体参与者的手指关节和前臂及鱼际的血管进行了成像。
结论
这项研究表明，基于小型化 MG 的 TAI 系统可用于具有多尺度分辨率（0.3-1.4mm）的体内关节和血管成像。
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