基于定位线的体内肝脏热声成像及演示。
In vivo liver thermoacoustic imaging and demonstration based on localization wire.
机构信息
Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, 610041, China.
School of Optoelectronic Engineering, Chongqing University of Posts and Telecommunications, Chongqing, 400065, China.
出版信息
Med Phys. 2021 Apr;48(4):1608-1615. doi: 10.1002/mp.14736. Epub 2021 Feb 24.
PURPOSE
Liver disease causes significant morbidity and mortality worldwide. Liver imaging plays an essential role in the noninvasive liver disease evaluation because of the limitation of liver biopsy. This paper aims to image in vivo liver with thermoacoustic imaging (TAI) and demonstrate this liver imaging technique with a cross-validation method.
METHODS
The imaging system composed of a large aperture antenna and a flexible transducer array was used, and we performed the position calibration using the delay and sum algorithm. The localization wire was utilized in the cross-validation of in vivo liver TAI.
RESULTS
We successfully validated in vivo liver TAI. In vivo images of different liver lobes without labels were observed. The imaging depth reached about 4 cm.
CONCLUSIONS
TAI has the potential to image the liver and provide useful dielectric properties of the liver tissue. This study realized the first in vivo liver TAI, suggesting its prospect in detecting liver disease noninvasively.
目的
肝脏疾病在全球范围内导致了大量的发病率和死亡率。由于肝活检的局限性，肝脏影像学在非侵入性肝脏疾病评估中起着至关重要的作用。本文旨在利用热声成像（TAI）对活体肝脏进行成像，并通过交叉验证方法验证这种肝脏成像技术。
方法
使用大孔径天线和柔性换能器阵列组成的成像系统，并使用延迟求和算法进行位置校准。在活体肝脏 TAI 的交叉验证中使用定位线。
结果
我们成功验证了活体肝脏 TAI。观察到没有标签的不同肝叶的活体图像。成像深度达到约 4 厘米。
结论
TAI 具有对肝脏进行成像并提供肝脏组织有用介电特性的潜力。本研究实现了首例活体肝脏 TAI，表明其在无创检测肝脏疾病方面具有广阔的前景。
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