Amorosi Cédric, Ball Vincent, Bour Jérôme, Bertani Philippe, Toniazzo Valérie, Ruch David, Averous Luc, Michel Marc
Department of Advanced Materials and Structures, Centre de Recherche Public Henri Tudor, 66 rue de Luxembourg, Esch-sur-Alzette, Luxembourg.
Department of Advanced Materials and Structures, Centre de Recherche Public Henri Tudor, 66 rue de Luxembourg, Esch-sur-Alzette, Luxembourg.
Mater Sci Eng C Mater Biol Appl. 2012 Oct 1;32(7):2103-2108. doi: 10.1016/j.msec.2012.05.045. Epub 2012 Jun 1.
Among various atmospheric pressure plasma deposition techniques, the so-called "Atmospheric Pressure Plasma Dielectric Barrier Discharges" (APDBD) has recently received a lot of attention due to the easy ignition of a stable discharge and its scalability. In the present work we aim at designing plasma polymer based films for biomedical applications, in which the drug to be released will be directly incorporated in the film during its deposition. Plasma polymer films made of methacrylic acid (MAA) and of ethylene glycol dimethacrylate (EGDMA) were prepared, allowing to obtain smart coatings able to release the molecule of interest, acetaminophen. A combination of different analytic tools shows that the functional groups of the film are well preserved with respect to the monomer structure and that the drug initially put in the gas phase is embedded in the plasma film with its structure being preserved. The physical and chemical characteristics of the elaborated film allowed for the progressive release of acetaminophen by simply dipping the film into a deionized water solution. However only 8% of the acetaminophen present in the monomer mixture could be released slowly in the presence of water. The significance of this result will be discussed.
在各种大气压等离子体沉积技术中，所谓的“大气压等离子体介质阻挡放电”（APDBD）最近因其稳定放电易于点燃及其可扩展性而备受关注。在本工作中，我们旨在设计用于生物医学应用的基于等离子体聚合物的薄膜，其中待释放的药物将在薄膜沉积过程中直接掺入其中。制备了由甲基丙烯酸（MAA）和乙二醇二甲基丙烯酸酯（EGDMA）制成的等离子体聚合物薄膜，从而获得了能够释放目标分子对乙酰氨基酚的智能涂层。不同分析工具的组合表明，薄膜的官能团相对于单体结构得到了很好的保留，并且最初置于气相中的药物以其结构得以保留的方式嵌入到等离子体薄膜中。通过将薄膜简单地浸入去离子水溶液中，所制备薄膜的物理和化学特性使得对乙酰氨基酚能够逐步释放。然而，在有水存在的情况下，单体混合物中仅8%的对乙酰氨基酚能够缓慢释放。将讨论该结果的意义。
