Department of Radiology, University Medical Center Regensburg, 93053 Regensburg, Germany.
Department of Pathology, University Medical Center Regensburg, 93053 Regensburg, Germany.
Cells. 2021 May 3;10(5):1092. doi: 10.3390/cells10051092.
In recent years contrast-enhanced ultrasound (CEUS) has been an emerging diagnostic modality for the detection of acute gastrointestinal (GI) graft-versus-host disease (GvHD) in patients after allogeneic stem cell transplantation. However, broad clinical usage has been partially limited by its high dependence on the expertise of an experienced examiner. Thus, the aim of this study was to facilitate detection of acute GI GvHD by implementing false color-coded parametric imaging of CEUS. As such, two inexperienced examiners with basic knowledge in abdominal and vascular ultrasound analyzed parametric images obtained from patients with clinical suspicion for acute GvHD in a blinded fashion. As diagnostic gold standard, histopathological GvHD severity score on intestinal biopsies obtained from lower GI tract endoscopy was performed. The evaluation of parametric images by the two inexperienced ultrasound examiners in patients with histological confirmation of acute GI GvHD was successful in 17 out of 19 patients (89%) as opposed to analysis of combined B-mode ultrasound, strain elastography, and CEUS by an experienced examiner, which was successful in 18 out of 19 of the patients (95%). Therefore, CEUS with parametric imaging of the intestine was technically feasible and has the potential to become a valuable diagnostic tool for rapid and widely accessible detection of acute GvHD in clinical practice.
近年来，对比增强超声（CEUS）已成为异体干细胞移植后患者急性胃肠道（GI）移植物抗宿主病（GvHD）检测的一种新兴诊断方式。然而，其广泛的临床应用受到了一定限制，部分原因是其对经验丰富的检查者的专业水平高度依赖。因此，本研究旨在通过实现 CEUS 的假彩色编码参数成像来促进急性 GI GvHD 的检测。为此，两名具有腹部和血管超声基础知识但经验不足的检查者以盲法分析了临床疑似急性 GvHD 患者的参数图像。以胃肠道活检的组织病理学 GvHD 严重程度评分为诊断金标准。对组织学证实为急性 GI GvHD 的患者的参数图像进行评估，两名经验不足的超声检查者在 17 例患者（89%）中成功完成，而由一名经验丰富的检查者进行的联合 B 模式超声、应变弹性成像和 CEUS 分析则在 19 例患者（95%）中成功完成。因此，肠的参数成像 CEUS 在技术上是可行的，并且有可能成为临床实践中快速、广泛应用的急性 GvHD 检测的有价值的诊断工具。
Zotero 插件
