吲哚菁绿辅助及LED光激活抗菌光动力疗法可减少牙菌斑。
Indocyanine Green-Assisted and LED-Light-Activated Antibacterial Photodynamic Therapy Reduces Dental Plaque.
作者信息
Nikinmaa Sakari, Moilanen Niina, Sorsa Timo, Rantala Juha, Alapulli Heikki, Kotiranta Anja, Auvinen Petri, Kankuri Esko, Meurman Jukka H, Pätilä Tommi
机构信息
Department of Neuroscience and Biomedical Engineering, Aalto University, 12200 Espoo, Finland.
Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland.
出版信息
Dent J (Basel). 2021 May 3;9(5):52. doi: 10.3390/dj9050052.
AIM
This study aimed to determine the feasibility and first efficacy of indocyanine green (ICG)-assisted antimicrobial photodynamictherapy (aPDT) as activated using LED light to the dental plaque.
METHODS
Fifteen healthy adults were assigned to this four-day randomized study. After rinsing with ICG, 100 J/cm of 810 nm LED light was applied to the aPDT-treatment area. Plaque area and gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-8) were measured, and plaque bacteriomes before and after the study were analyzed using 16S rRNA sequencing.
RESULTS
aPDT administration was preformed successfully and plaque-specifically with the combination of ICG and the applicator. Total plaque area and endpoint MMP-8 levels were reduced on the aPDT-treatment side. aPDT reduced , , , and bacteria species in plaques.
CONCLUSION
ICG-assisted aPDT reduces plaque forming bacteria and exerts anti-inflammatory and anti-proteolytic effects.
目的
本研究旨在确定使用吲哚菁绿（ICG）辅助的抗菌光动力疗法（aPDT）并通过LED光激活，对牙菌斑的可行性和初步疗效。
方法
15名健康成年人被纳入这项为期四天的随机研究。用ICG冲洗后，将100 J/cm的810 nm LED光照射到aPDT治疗区域。测量菌斑面积和龈沟液（GCF）基质金属蛋白酶-8（MMP-8），并使用16S rRNA测序分析研究前后的菌斑菌群。
结果
aPDT给药通过ICG和涂抹器的组合成功且具有菌斑特异性地完成。aPDT治疗侧的总菌斑面积和终点MMP-8水平降低。aPDT减少了菌斑中的 、 、 和 细菌种类。
结论
ICG辅助的aPDT减少形成菌斑的细菌，并发挥抗炎和抗蛋白水解作用。
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