癌症与食管动力障碍疾病关联的机制。
The Mechanisms for the Association of Cancer and Esophageal Dysmotility Disorders.
机构信息
Hospital Israelita Albert Einstein, Sao Paulo 05652-900, Brazil.
Department of Gastroenterology, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 05403-000, Brazil.
出版信息
Med Sci (Basel). 2021 May 21;9(2):32. doi: 10.3390/medsci9020032.
BACKGROUND
Achalasia and other esophageal dysmotility disorders mimicking achalasia can be associated with cancer. This study aimed to review the main mechanisms for which cancer may develop in esophageal dysmotility disorder patients.
METHODS
A narrative review was performed.
RESULTS
The mechanism for developing squamous cell carcinoma and adenocarcinoma are discussed. Besides, achalasia-like syndromes related to familial KIT-gene mutation and pseudoachalasia are discussed.
CONCLUSIONS
Knowing the main mechanism for which achalasia can be related to cancer is essential for clinicians to conduct the proper investigation, surveillance, and treatment.
背景
贲门失弛缓症和其他类似贲门失弛缓症的食管动力障碍性疾病可能与癌症有关。本研究旨在综述癌症可能在食管动力障碍性疾病患者中发展的主要机制。
方法
进行了叙述性综述。
结果
讨论了发展鳞状细胞癌和腺癌的机制。此外，还讨论了与家族性 KIT 基因突变相关的贲门失弛缓样综合征和假性贲门失弛缓症。
结论
了解贲门失弛缓症与癌症相关的主要机制对于临床医生进行适当的检查、监测和治疗至关重要。
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