Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.
Molecules. 2021 May 4;26(9):2693. doi: 10.3390/molecules26092693.
Whether the retinoic acid-related orphan receptor (ROR) is a nuclear receptor of melatonin remains controversial. ROR is inextricably linked to melatonin in terms of its expression, function, and mechanism of action. Additionally, studies have illustrated that melatonin functions analogous to ROR ligands, thereby modulating the transcriptional activity of ROR. However, studies supporting these interactions have since been withdrawn. Furthermore, recent crystallographic evidence does not support the view that ROR is a nuclear receptor of melatonin. Some other studies have proposed that melatonin indirectly regulates ROR activity rather than directly binding to ROR. This review aims to delve into the complex relationship of the ROR receptor with melatonin in terms of its structure, expression, function, and mechanism. Thus, we provide the latest evidence and views on direct binding as well as indirect regulation of ROR by melatonin, dissecting both viewpoints in-depth to provide a more comprehensive perspective on this issue.
视黄酸相关孤儿受体（ROR）是否为褪黑素的核受体尚存争议。从表达、功能和作用机制方面来看，ROR 与褪黑素密不可分。此外，研究表明，褪黑素的功能类似于 ROR 配体，从而调节 ROR 的转录活性。然而，自此之后，支持这些相互作用的研究已被撤回。此外，最近的晶体学证据并不支持 ROR 是褪黑素的核受体这一观点。一些其他研究提出，褪黑素间接调节 ROR 活性，而不是直接与 ROR 结合。本综述旨在深入探讨 ROR 受体与褪黑素在结构、表达、功能和机制方面的复杂关系。因此，我们提供了关于褪黑素直接结合以及间接调节 ROR 的最新证据和观点，深入剖析了这两种观点，以期更全面地了解这一问题。
