Mehrzadi Mohammad Hossein, Hosseinzadeh Azam, Juybari Kobra Bahrampour, Mehrzadi Saeed
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Cancer Cell Int. 2020 Sep 10;20:444. doi: 10.1186/s12935-020-01531-1. eCollection 2020.
Urological cancers are responsible for thousands of cancer-related deaths around the world. Despite all developments in therapeutic approaches for cancer therapy, the absence of efficient treatments is a critical and vital problematic issue for physicians and researchers. Furthermore, routine medical therapies contribute to several undesirable adverse events for patients, reducing life quality and survival time. Therefore, many attempts are needed to explore potent alternative or complementary treatments for great outcomes. Melatonin has multiple beneficial potential effects, including anticancer properties. Melatonin in combination with chemoradiation therapy or even alone could suppress urological cancers through affecting essential cellular pathways. This review discusses current evidence reporting the beneficial effect of melatonin in urological malignancies, including prostate cancer, bladder cancer, and renal cancer.
泌尿系统癌症在全球导致了数千例与癌症相关的死亡。尽管癌症治疗方法有了种种进展，但缺乏有效的治疗手段对医生和研究人员来说仍是一个至关重要且亟待解决的问题。此外，常规医学疗法会给患者带来一些不良的副作用，降低生活质量和缩短生存时间。因此，需要进行多种尝试来探索有效的替代或辅助治疗方法以取得更好的治疗效果。褪黑素具有多种有益的潜在作用，包括抗癌特性。褪黑素与放化疗联合使用甚至单独使用都可以通过影响关键细胞通路来抑制泌尿系统癌症。本综述讨论了目前有关褪黑素对泌尿系统恶性肿瘤（包括前列腺癌、膀胱癌和肾癌）有益作用的证据。
