Vercruysse J, Fransen J, Southgate V R, Rollinson D, Majeleine W
Department of Parasitology, Faculty of Veterinary Medicine, Ghent, Belgium.
Res Vet Sci. 1988 May;44(3):273-81.
The clinical pathology of Schistosoma curassoni infection in sheep and goats was studied for 22 weeks following experimental infection with 7000 and 4000 cercariae, respectively. Excretion of eggs began at week 7 after infection: in goats the numbers increased to 30 to 50 eggs per gram faeces (epg) at weeks 8 to 18, followed by a reduction. In a pregnant goat, epg values increased markedly before and after parturition. The mean faecal egg counts in sheep were lower than in goats, increasing to a maximum level of 30 epg at weeks 16 and 17 after infection. Infected sheep maintained growth rates roughly comparable with controls, whereas infected goats failed to gain as much weight as the controls. Infected goats and sheep produced eosinophil counts of about 3 x 10(3) mm-3, five and eight weeks after infection, respectively. Sheep developed a progressive anaemia from week 11 after infection, in goats blood values remained within normal limits. Differences in serum protein concentration were observed between infected and uninfected goats about nine weeks after infection, but not in sheep. Increased total protein values, hyperglobulinaemia and lowered albumin to globulin ratios were features of infected goats. Serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, gamma-glutamyl transferase, total lactate dehydrogenase and bilirubin were not significantly changed. The mean recovery in sheep was 608 worms, in goats 428 worms, but the total tissue egg counts were higher in the latter. Of the total eggs deposited in the goats 92 per cent were found in the liver with 51.5 per cent in the ovine liver. The histopathological changes were studied.
分别用7000只和4000只尾蚴对绵羊和山羊进行实验性感染后，对其感染柯氏血吸虫的临床病理学进行了为期22周的研究。感染后第7周开始排虫卵：山羊在感染后第8至18周，每克粪便中的虫卵数增加到30至50个（epg），随后减少。在一只怀孕的山羊中，分娩前后epg值显著增加。绵羊粪便中虫卵的平均计数低于山羊，在感染后第16和17周增加到最高水平30 epg。受感染的绵羊维持的生长速度与对照组大致相当，而受感染的山羊体重增加不如对照组。受感染的山羊和绵羊分别在感染后5周和8周产生约3×10³/mm³的嗜酸性粒细胞计数。绵羊从感染后第11周开始出现进行性贫血，山羊的血液值保持在正常范围内。感染和未感染的山羊在感染后约9周观察到血清蛋白浓度存在差异，但绵羊没有。总蛋白值增加、高球蛋白血症以及白蛋白与球蛋白比值降低是受感染山羊的特征。血清谷氨酸草酰乙酸转氨酶、谷氨酸丙酮酸转氨酶、γ-谷氨酰转移酶、总乳酸脱氢酶和胆红素没有显著变化。绵羊体内平均回收608条虫，山羊体内回收428条虫，但后者组织中的虫卵总数更高。在山羊体内沉积的虫卵中，92%在肝脏中发现，其中51.5%在绵羊肝脏中。对组织病理学变化进行了研究。
