SURVEN (Nutrition Surveillance and Epidemiology in Tunisia) Research Laboratory, INNTA (National Institute of Nutrition and Food Technology), 11 Rue Jebel Lakhdar, bab Saadoun, 1007 Tunis, Tunisia.
Laboratory Materials Molecules and Applications, IPEST (Preparatory Institute for Scientific and Technical Studies), University of Carthage, P.B. 51, 2070 Tunis, Tunisia.
Int J Environ Res Public Health. 2021 May 20;18(10):5461. doi: 10.3390/ijerph18105461.
The protective role of high high-density lipoprotein cholesterol (HDL-C) against cardiovascular risk has been questioned recently. Due to the increasing trend of cardiovascular diseases (CVD) in Tunisia, this study aimed to determine the prevalence of high HDL-C and its associated factors in Tunisian women of childbearing age. A cross-sectional survey was conducted among a subsample of 1689 women, aged 20 to 49 years, in the Great Tunis region. Data on socio-demographic and lifestyle factors were collected by a questionnaire. Overall adiposity was assessed by body mass index (BMI). All biological variables were assayed in blood samples coated with anticoagulant ethylene diamine tetra acetic acid (EDTA) by enzymatic methods. Stata software (2015) was used for data management and statistical analysis. High HDL-C values were recorded in 26.6% of selected women. After adjustment for all socio-demographic and lifestyle factors, age, hypertension, and smoking were negatively associated with high HDL-C levels, while family history of cancer was positively associated with high HDL-C in women. An additional investigation on the relationship between high HDL-C and cancer risk should be performed due to controversial results.
最近，人们对高高密度脂蛋白胆固醇（HDL-C）对心血管风险的保护作用提出了质疑。由于突尼斯心血管疾病（CVD）的发病率不断上升，本研究旨在确定生育年龄段突尼斯妇女高 HDL-C 的流行情况及其相关因素。在大突尼斯地区，对 1689 名年龄在 20 至 49 岁的妇女进行了一项横断面调查。通过问卷收集了社会人口统计学和生活方式因素的数据。总体肥胖程度通过体重指数（BMI）评估。所有生物变量均通过酶法在涂有抗凝剂乙二胺四乙酸（EDTA）的血样中进行检测。使用 Stata 软件（2015 年）进行数据管理和统计分析。在所选择的女性中，有 26.6%的人记录了高 HDL-C 值。在调整了所有社会人口统计学和生活方式因素后，年龄、高血压和吸烟与高 HDL-C 水平呈负相关，而癌症家族史与女性高 HDL-C 呈正相关。由于结果存在争议，应该对高 HDL-C 与癌症风险之间的关系进行进一步研究。
