神经系统疾病患者脑脊液中血浆来源蛋白的性别差异
Sex-Related Differences in Cerebrospinal Fluid Plasma-Derived Proteins of Neurological Patients.
作者信息
Castellazzi Massimiliano, Ferri Caterina, Alfiero Sarah, Lombardo Ilenia, Laudisi Michele, Tecilla Ginevra, Boni Michela, Pizzicotti Stefano, Fainardi Enrico, Bellini Tiziana, Pugliatti Maura
机构信息
Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Interdepartmental Research Center for the Study of Multiple Sclerosis and Inflammatory and Degenerative Diseases of the Nervous System, University of Ferrara, 44121 Ferrara, Italy.
出版信息
Diagnostics (Basel). 2021 May 16;11(5):884. doi: 10.3390/diagnostics11050884.
BACKGROUND AND AIMS
Cerebrospinal fluid (CSF) protein content presents a sexual dimorphism in humans. We investigated sex-related differences in CSF IgG levels and in the quantification of intrathecal IgG synthesis (IIS).
METHODS
CSF, serum albumin and IgG were measured in 1519 neurological patients and both linear and hyperbolic formulas were used for the quantification of IIS. CSF-restricted oligoclonal IgG bands (OCBs) were used as "gold standard".
RESULTS
The linear IgG Index showed a weak agreement with OCBs in males and females (k = 0.559, k = 0.587, respectively), while the hyperbolic Reiber's formulas had a moderate agreement with OCBs in females (k = 0.635) and a weak agreement in males (k = 0.565). Higher CSF albumin and IgG levels were found in men than in women in the whole population and in subjects without IIS after adjusting for age and for serum concentrations of albumin and IgG, respectively (Quade statistics, < 0.000001). CSF and serum albumin and IgG levels positively correlated to age in both sexes. CSF total protein content did not correlate with CSF leukocyte numbers but was higher in patients with marked pleocytosis.
CONCLUSIONS
In neurological patients, men have higher levels of CSF serum-derived proteins, such as albumin and IgG.
背景与目的
脑脊液（CSF）蛋白质含量在人类中存在性别差异。我们研究了脑脊液IgG水平及鞘内IgG合成（IIS）定量方面的性别相关差异。
方法
对1519例神经科患者测定了脑脊液、血清白蛋白和IgG，并使用线性公式和双曲线公式对IIS进行定量。脑脊液限制性寡克隆IgG带（OCBs）用作“金标准”。
结果
线性IgG指数在男性和女性中与OCBs的一致性较弱（分别为k = 0.559，k = 0.587），而双曲线Reiber公式在女性中与OCBs的一致性中等（k = 0.635），在男性中一致性较弱（k = 0.565）。在调整年龄以及血清白蛋白和IgG浓度后，在整个人群以及无IIS的受试者中，男性的脑脊液白蛋白和IgG水平高于女性（Quade统计，< 0.000001）。脑脊液和血清白蛋白及IgG水平在两性中均与年龄呈正相关。脑脊液总蛋白含量与脑脊液白细胞数量无关，但在明显细胞增多的患者中更高。
结论
在神经科患者中，男性脑脊液中源自血清的蛋白质（如白蛋白和IgG）水平较高。
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