Marler M R, Jacob R G, Lehoczky J P, Shapiro A P
Department of Psychiatry, Cleveland Metropolitan General Hospital, OH 44102.
Stat Med. 1988 Jun;7(6):697-716. doi: 10.1002/sim.4780070608.
This paper presents a statistical analysis of treatment effects in 24-hour ambulatory blood pressure recordings. The statistical models account for circadian rhythms, subject effects, and the effects of treatment with drugs or relaxation therapy. In view of the heterogeneity of the subjects, we fit a separate linear model to the data of each subject, use robust statistical procedures to estimate the parameters of the linear models, and trim the data on a subject by subject basis. We use a meta-analytical method to combine the results of all subjects in the study.
本文介绍了对24小时动态血压记录中的治疗效果进行的统计分析。统计模型考虑了昼夜节律、个体效应以及药物治疗或放松疗法的效果。鉴于受试者的异质性，我们为每个受试者的数据拟合一个单独的线性模型，使用稳健的统计程序来估计线性模型的参数，并逐个受试者地对数据进行修剪。我们使用荟萃分析方法来合并研究中所有受试者的结果。
