Zhang Ze
College of Life Sciences, Beijing Normal University, Beijing 100875, China.
National Institute of Biological Sciences, Zhongguancun Life Science Park, Beijing 102206, China.
Pathogens. 2021 May 6;10(5):558. doi: 10.3390/pathogens10050558.
, often referred to as group B streptococci (GBS), is a severe pathogen that can infect humans as well as other animals, including tilapia, which is extremely popular in commercial aquaculture. This pathogen causes enormous pecuniary loss, and typical symptoms of streptococcosis-the disease caused by -include abnormal behavior, exophthalmos, and meningitis, among others. Multiple studies have examined virulence factors associated with infection, and vaccines were explored, including studies of subunit vaccines. Known virulence factors include capsular polysaccharide (CPS), hemolysin, Christie-Atkins-Munch-Peterson (CAMP) factor, hyaluronidase (HAase), superoxide dismutase (SOD), and serine-threonine protein kinase (STPK), and effective vaccine antigens reported to date include GapA, Sip, OCT, PGK, FbsA, and EF-Tu. In this review, I summarize findings from several studies about the etiology, pathology, virulence factors, and vaccine prospects for . I end by considering which research areas are likely to yield success in the prevention and treatment of tilapia streptococcosis.
，通常被称为B组链球菌（GBS），是一种严重的病原体，可感染人类以及其他动物，包括在商业水产养殖中极为常见的罗非鱼。这种病原体造成巨大的经济损失，由其引起的疾病——链球菌病的典型症状包括行为异常、眼球突出和脑膜炎等。多项研究已经检测了与感染相关的毒力因子，并探索了疫苗，包括亚单位疫苗的研究。已知的毒力因子包括荚膜多糖（CPS）、溶血素、克里斯蒂-阿特金斯-芒奇-彼得森（CAMP）因子、透明质酸酶（HAase）、超氧化物歧化酶（SOD）和丝氨酸-苏氨酸蛋白激酶（STPK），迄今为止报道的有效疫苗抗原有GapA、Sip、OCT、PGK、FbsA和EF-Tu。在这篇综述中，我总结了几项关于的病因、病理、毒力因子和疫苗前景的研究结果。最后，我思考了哪些研究领域可能在罗非鱼链球菌病的预防和治疗方面取得成功。
