Jayashree S, Bhan M K, Raj P, Kumar R, Svensson L, Stintzing G, Bhandari N
Department of Paediatrics, All India Institute of Medical Sciences, New Delhi.
Scand J Infect Dis. 1988;20(3):249-53. doi: 10.3109/00365548809032447.
Among 274 neonates born at the maternity services of an urban hospital in India, 36.1% of the infants shed rotavirus in feces (as detected by ELISA) by 72 h of life. The excretion rate increased to 70.3% among the 120 infants who stayed for 5 days or more at the hospital. Diarrhoeal symptoms of mild and self-limited nature were observed only in 19.2% of the rotavirus excretors, the remaining being asymptomatic. Among the 98 infants who received supplement feeds, 49% acquired rotavirus infection as against 24.7% of the 150 exclusively breast fed infants (p less than 0.001). Viral RNA in the feces of all rota positive infants showed the same electropherotype, indicating infection from a common source. The mean percentage rotavirus inhibitory activity of cord sera in the infected and non-infected infants was 50.2 +/- 21.7 and 56.6 +/- 19.2 respectively (p greater than 0.05), suggesting that cord blood antibodies do not offer significant protection against neonatal rotavirus infection.
在印度一家城市医院产科出生的274名新生儿中，36.1%的婴儿在出生72小时内粪便中排出轮状病毒（通过ELISA检测）。在医院停留5天或更长时间的120名婴儿中，排泄率增至70.3%。仅19.2%的轮状病毒排泄者出现轻度自限性腹泻症状，其余均无症状。在98名接受补充喂养的婴儿中，49%感染了轮状病毒，而150名纯母乳喂养婴儿的感染率为24.7%（p<0.001）。所有轮状病毒阳性婴儿粪便中的病毒RNA显示相同的电泳图谱型，表明感染源自同一来源。感染和未感染婴儿脐带血清中轮状病毒抑制活性的平均百分比分别为50.2±21.7和56.6±19.2（p>0.05），这表明脐带血抗体对新生儿轮状病毒感染没有显著的保护作用。
