Gene, the GATA Transcription Activator, Regulates the Production of Higher Alcohol during Wheat Beer Fermentation by .

Uncoordinated carbon-nitrogen ratio in raw materials will lead to excessive contents of higher alcohols in alcoholic beverages. The effect of gene, the GATA transcription activator, on higher alcohol biosynthesis was investigated to clarify the mechanism of regulating higher alcohol metabolism under high concentrations of free amino nitrogen (FAN). The availability of FAN by strain SDT1K with a double-copy deletion was 28.31% lower than that of parent strain S17, and the yield of higher alcohols was 33.91% lower. The transcript levels of the downstream target genes of and higher alcohol production in the double-copy deletion mutant suggested that a part of the effect of deletion on higher alcohol production was the downregulation of , , and . This study shows that GATA factors can effectively regulate the metabolism of higher alcohols in and provides valuable insights into higher alcohol biosynthesis, showing great significance for the wheat beer industry.