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对克鲁彭科等人的回复。关于“李等人。2020年，ALDH1L1功能丧失与二甲双胍治疗联合降低KRAS驱动的肺癌肿瘤生长，，1382”的评论。

Reply to Krupenko et al. Comment on "Lee et al. The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer 2020, , 1382".

作者信息

Lee Seon-Hyeong, Jeon Yoon, Kang Joon-Hee, Jang Hyonchol, Hong Kyeong-Man, Hong Dongwan, Lee Ho, Kim Soo-Youl

机构信息

Division of Cancer Biology, Research Institute, National Cancer Center, Goyang 10408, Korea.

Department of Medical Informatics, College of Medicine, Catholic University of Korea, Seoul 06591, Korea.

出版信息

Cancers (Basel). 2021 May 7;13(9):2238. doi: 10.3390/cancers13092238.

DOI:10.3390/cancers13092238
PMID:34066916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8124425/
Abstract

In the Cancers paper, we observed the increase ALDH1L1 protein expression following oncogenesis, as well as a therapeutic effect, by deleting the gene in mice, a model of spontaneous non-small cell lung cancer (NSCLC) [...].

摘要

在《癌症》杂志的论文中，我们观察到致癌作用后ALDH1L1蛋白表达增加，以及通过在自发非小细胞肺癌（NSCLC）小鼠模型中删除该基因所产生的治疗效果[……]

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/a3824d8b8d79/cancers-13-02238-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/e7289ec27ac6/cancers-13-02238-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/e300d5e0edda/cancers-13-02238-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/7ecaa6ad5d60/cancers-13-02238-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/0d0988fa700b/cancers-13-02238-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/781e1112655f/cancers-13-02238-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/1db02c3e9806/cancers-13-02238-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/bf2f650a16ed/cancers-13-02238-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/169ec3679ebd/cancers-13-02238-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/fe39387992f8/cancers-13-02238-g009a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/fed138c375bb/cancers-13-02238-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/a3824d8b8d79/cancers-13-02238-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/e7289ec27ac6/cancers-13-02238-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/e300d5e0edda/cancers-13-02238-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/7ecaa6ad5d60/cancers-13-02238-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/0d0988fa700b/cancers-13-02238-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/781e1112655f/cancers-13-02238-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/1db02c3e9806/cancers-13-02238-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/bf2f650a16ed/cancers-13-02238-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/169ec3679ebd/cancers-13-02238-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/fe39387992f8/cancers-13-02238-g009a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/fed138c375bb/cancers-13-02238-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2603/8124425/a3824d8b8d79/cancers-13-02238-g011.jpg

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Reply to Krupenko et al. Comment on "Lee et al. The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer 2020, , 1382".对克鲁彭科等人的回复。关于“李等人。2020年，ALDH1L1功能丧失与二甲双胍治疗联合降低KRAS驱动的肺癌肿瘤生长，，1382”的评论。
Cancers (Basel). 2021 May 7;13(9):2238. doi: 10.3390/cancers13092238.
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Is ALDH1L1 Elevated in Lung Cancer? Comment on: Lee, S.-H.; et al. "The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer" 2020, , 1382.肺癌中醛脱氢酶1L1（ALDH1L1）水平会升高吗？评：Lee, S.-H.等人，《醛脱氢酶1L1功能丧失与二甲双胍治疗联合可降低KRAS驱动的肺癌肿瘤生长》，2020年，，1382。
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引用本文的文献

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Human Aldehyde Dehydrogenases: A Superfamily of Similar Yet Different Proteins Highly Related to Cancer.人类乙醛脱氢酶：与癌症高度相关的相似却又不同的蛋白质超家族。
Cancers (Basel). 2023 Sep 4;15(17):4419. doi: 10.3390/cancers15174419.

本文引用的文献

1
The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in -Driven Lung Cancer.ALDH1L1功能丧失与二甲双胍治疗相结合可降低驱动型肺癌的肿瘤生长。
Cancers (Basel). 2020 May 28;12(6):1382. doi: 10.3390/cancers12061382.
2
Aldehyde dehydrogenase is used by cancer cells for energy metabolism.醛脱氢酶被癌细胞用于能量代谢。
Exp Mol Med. 2016 Nov 25;48(11):e272. doi: 10.1038/emm.2016.103.
3
Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion.
乙醛脱氢酶抑制与苯乙双胍联合治疗通过消耗ATP逆转非小细胞肺癌。
Oncotarget. 2016 Aug 2;7(31):49397-49410. doi: 10.18632/oncotarget.10354.
4
Exploring TCGA Pan-Cancer data at the UCSC Cancer Genomics Browser.探索 UCSC 癌症基因组浏览器中的 TCGA 泛癌症数据。
Sci Rep. 2013 Oct 2;3:2652. doi: 10.1038/srep02652.
5
Aldehyde dehydrogenase 1A1 possesses stem-like properties and predicts lung cancer patient outcome.乙醛脱氢酶 1A1 具有干细胞样特性，并可预测肺癌患者的预后。
J Thorac Oncol. 2012 Aug;7(8):1235-45. doi: 10.1097/JTO.0b013e318257cc6d.
6
Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer.醛脱氢酶1是肺癌中一种与肿瘤干细胞相关的标志物。
Mol Cancer Res. 2009 Mar;7(3):330-8. doi: 10.1158/1541-7786.MCR-08-0393. Epub 2009 Mar 10.
7
FDH: an aldehyde dehydrogenase fusion enzyme in folate metabolism.FDH：叶酸代谢中的一种醛脱氢酶融合酶。
Chem Biol Interact. 2009 Mar 16;178(1-3):84-93. doi: 10.1016/j.cbi.2008.09.007. Epub 2008 Sep 19.
8
Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease.烟酰胺腺嘌呤二核苷酸，一种转录、寿命和疾病的代谢调节因子。
Curr Opin Cell Biol. 2003 Apr;15(2):241-6. doi: 10.1016/s0955-0674(03)00006-1.
9
Expression, purification, and properties of the aldehyde dehydrogenase homologous carboxyl-terminal domain of rat 10-formyltetrahydrofolate dehydrogenase.大鼠10-甲酰四氢叶酸脱氢酶醛脱氢酶同源羧基末端结构域的表达、纯化及性质
J Biol Chem. 1997 Apr 11;272(15):10266-72. doi: 10.1074/jbc.272.15.10266.
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