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肺癌中醛脱氢酶1L1（ALDH1L1）水平会升高吗？评：Lee, S.-H.等人，《醛脱氢酶1L1功能丧失与二甲双胍治疗联合可降低KRAS驱动的肺癌肿瘤生长》，2020年，，1382。

Is ALDH1L1 Elevated in Lung Cancer? Comment on: Lee, S.-H.; et al. "The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer" 2020, , 1382.

作者信息

Krupenko Sergey A, Sharma Jaspreet

机构信息

Department of Nutrition and Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA.

出版信息

Cancers (Basel). 2021 Apr 2;13(7):1691. doi: 10.3390/cancers13071691.

DOI:10.3390/cancers13071691
PMID:33918472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8038273/
Abstract

We read with interest the article by Lee et al [...].

摘要

我们饶有兴趣地阅读了Lee等人撰写的文章[……]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6105/8038273/b781acdfc83b/cancers-13-01691-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6105/8038273/b781acdfc83b/cancers-13-01691-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6105/8038273/b781acdfc83b/cancers-13-01691-g001.jpg

相似文献

1
Is ALDH1L1 Elevated in Lung Cancer? Comment on: Lee, S.-H.; et al. "The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer" 2020, , 1382.肺癌中醛脱氢酶1L1（ALDH1L1）水平会升高吗？评：Lee, S.-H.等人，《醛脱氢酶1L1功能丧失与二甲双胍治疗联合可降低KRAS驱动的肺癌肿瘤生长》，2020年，，1382。
Cancers (Basel). 2021 Apr 2;13(7):1691. doi: 10.3390/cancers13071691.
2
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Cancers (Basel). 2021 May 7;13(9):2238. doi: 10.3390/cancers13092238.
3
The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in -Driven Lung Cancer.ALDH1L1功能丧失与二甲双胍治疗相结合可降低驱动型肺癌的肿瘤生长。
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Targeting oncogenic KRAS in non-small cell lung cancer cells by phenformin inhibits growth and angiogenesis.二甲双胍靶向非小细胞肺癌细胞中的致癌性KRAS可抑制其生长和血管生成。
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Phenformin enhances the therapeutic effect of selumetinib in KRAS-mutant non-small cell lung cancer irrespective of LKB1 status.无论LKB1状态如何，苯乙双胍均可增强司美替尼对KRAS突变型非小细胞肺癌的治疗效果。
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Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion.乙醛脱氢酶抑制与苯乙双胍联合治疗通过消耗ATP逆转非小细胞肺癌。
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Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression.ALDH1L1 叶酸酶的缺失赋予了肿瘤进展的选择性代谢优势。
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CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase.CHIP E3 连接酶在 NIH3T3 成纤维细胞从 G0/G1 期向 S 期过渡过程中，介导增殖调节蛋白 ALDH1L1 的蛋白酶体降解。
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Comment on Hopkins et al. Value of the Lung Immune Prognostic Index in Patients with Non-Small Cell Lung Cancer Initiating First-Line Atezolizumab Combination Therapy: Subgroup Analysis of the IMPOWER150 Trial. 2021, , 1176.关于霍普金斯等人的评论。肺免疫预后指数在非小细胞肺癌患者一线阿替唑单抗联合治疗中的价值：IMPOWER150试验的亚组分析。2021年，，1176。
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引用本文的文献

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Human Aldehyde Dehydrogenases: A Superfamily of Similar Yet Different Proteins Highly Related to Cancer.人类乙醛脱氢酶：与癌症高度相关的相似却又不同的蛋白质超家族。
Cancers (Basel). 2023 Sep 4;15(17):4419. doi: 10.3390/cancers15174419.
2
Exploratory Metabolomics Underscores the Folate Enzyme ALDH1L1 as a Regulator of Glycine and Methylation Reactions.探索性代谢组学强调叶酸酶 ALDH1L1 是甘氨酸和甲基化反应的调节剂。
Molecules. 2022 Dec 1;27(23):8394. doi: 10.3390/molecules27238394.

本文引用的文献

1
The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in -Driven Lung Cancer.ALDH1L1功能丧失与二甲双胍治疗相结合可降低驱动型肺癌的肿瘤生长。
Cancers (Basel). 2020 May 28;12(6):1382. doi: 10.3390/cancers12061382.
2
Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression.ALDH1L1 叶酸酶的缺失赋予了肿瘤进展的选择性代谢优势。
Chem Biol Interact. 2019 Apr 1;302:149-155. doi: 10.1016/j.cbi.2019.02.013. Epub 2019 Feb 20.
3
Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism.
肝 NADH 和 NADPH 代谢的时空区隔化。
J Biol Chem. 2018 May 18;293(20):7508-7516. doi: 10.1074/jbc.TM117.000258. Epub 2018 Mar 7.
4
Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion.乙醛脱氢酶抑制与苯乙双胍联合治疗通过消耗ATP逆转非小细胞肺癌。
Oncotarget. 2016 Aug 2;7(31):49397-49410. doi: 10.18632/oncotarget.10354.
5
Aldehyde dehydrogenase 1A1 possesses stem-like properties and predicts lung cancer patient outcome.乙醛脱氢酶 1A1 具有干细胞样特性，并可预测肺癌患者的预后。
J Thorac Oncol. 2012 Aug;7(8):1235-45. doi: 10.1097/JTO.0b013e318257cc6d.
6
Epigenetic Silencing of ALDH1L1, a Metabolic Regulator of Cellular Proliferation, in Cancers.醛脱氢酶1家族成员L1（ALDH1L1）作为细胞增殖的代谢调节因子在癌症中的表观遗传沉默
Genes Cancer. 2011 Feb;2(2):130-9. doi: 10.1177/1947601911405841.
7
ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase.ALDH1L2 是 10-甲酰四氢叶酸脱氢酶的线粒体同源物。
J Biol Chem. 2010 Jul 23;285(30):23056-63. doi: 10.1074/jbc.M110.128843. Epub 2010 May 24.
8
Addressing a folate imbalance in fetal cerebrospinal fluid can decrease the incidence of congenital hydrocephalus.解决胎儿脑脊液中的叶酸失衡问题可以降低先天性脑积水的发病率。
J Neuropathol Exp Neurol. 2009 Apr;68(4):404-16. doi: 10.1097/NEN.0b013e31819e64a7.
9
Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer.醛脱氢酶1是肺癌中一种与肿瘤干细胞相关的标志物。
Mol Cancer Res. 2009 Mar;7(3):330-8. doi: 10.1158/1541-7786.MCR-08-0393. Epub 2009 Mar 10.
10
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function.一个针对星形胶质细胞、神经元和少突胶质细胞的转录组数据库：理解大脑发育和功能的新资源。
J Neurosci. 2008 Jan 2;28(1):264-78. doi: 10.1523/JNEUROSCI.4178-07.2008.