Biotechnology Engineering Department, Kulliyyah of Engineering, International Islamic University, Malaysia (IIUM), P.O. Box 10, Gombak, Kuala Lumpur 50728, Malaysia.
International Institute for Halal Research and Training (INHART), Level 3, KICT Building, International Islamic University Malaysia (IIUM), Jalan Gombak, Kuala Lumpur 53100, Malaysia.
Molecules. 2021 May 7;26(9):2741. doi: 10.3390/molecules26092741.
Leukemia is a leukocyte cancer that is characterized by anarchic growth of immature immune cells in the bone marrow, blood and spleen. There are many forms of leukemia, and the best course of therapy and the chance of a patient's survival depend on the type of leukemic disease. Different forms of drugs have been used to treat leukemia. Due to the adverse effects associated with such therapies and drug resistance, the search for safer and more effective drugs remains one of the most challenging areas of research. Thus, new therapeutic approaches are important to improving outcomes. Almost half of the drugs utilized nowadays in treating cancer are from natural products and their derivatives. Medicinal plants have proven to be an effective natural source of anti-leukemic drugs. The cytotoxicity and the mechanisms underlying the toxicity of these plants to leukemic cells and their isolated compounds were investigated. Effort has been made throughout this comprehensive review to highlight the recent developments and milestones achieved in leukemia therapies using plant-derived compounds and the crude extracts from various medicinal plants. Furthermore, the mechanisms of action of these plants are discussed.
白血病是一种白细胞癌，其特征是骨髓、血液和脾脏中不成熟免疫细胞的无序生长。白血病有多种形式，最佳治疗方案和患者的生存机会取决于白血病的类型。已经使用了不同形式的药物来治疗白血病。由于与这些治疗方法相关的不良反应和耐药性，寻找更安全、更有效的药物仍然是研究的最具挑战性领域之一。因此，新的治疗方法对于改善治疗效果至关重要。目前用于治疗癌症的药物中，近一半来自天然产物及其衍生物。药用植物已被证明是抗白血病药物的有效天然来源。研究了这些植物对白血病细胞及其分离化合物的细胞毒性和毒性机制。在本综述中，我们努力强调使用植物衍生化合物和各种药用植物的粗提取物治疗白血病方面的最新进展和里程碑式成就。此外，还讨论了这些植物的作用机制。
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