• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

优化用于血癌治疗的肿瘤治疗电场：电场分布与剂量密度分析

Optimizing tumor treating fields for blood cancer therapy: Analysis of electric field distribution and dose density.

作者信息

Nasori Nasori, Firdhaus Miftakhul, Farahdina Ulya, Khamimatul Ula Rini

机构信息

Laboratory of Medical Physics and Biophysics, Department of Physics, Faculty Science and Data Analytic, Institute Teknologi Sepuluh Nopember, Surabaya 60111, Indonesia.

Research Center Of Electronics, National Research and Innovation Agency of Indonesia (BRIN), Jakarta, 10340, Indonesia and Nusa Putra University, Sukabumi, Indonesia.

出版信息

Biophys Physicobiol. 2024 Apr 18;21(2):e210013. doi: 10.2142/biophysico.bppb-v21.0013. eCollection 2024.

DOI:10.2142/biophysico.bppb-v21.0013
PMID:39206129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11347819/
Abstract

Blood cancer is a condition in which white blood cells grow uncontrollably. Tumor treating fields (TTF) are a modality of cancer treatment that utilizes electric fields to target malignant cells. To optimize the efficacy of TTF, it is necessary to investigate the distribution of electric field through varying electrode configurations and input parameters. This allows for enhancement of electric field intensity in targeted areas while minimizing intensity in sensitive areas. Analysis of electric field distribution was conducted through simulation of brachial models with varying electrode configurations and input parameters, utilizing the COMSOL Multiphysics 5.4 software. Additionally, investigations were carried out to assess tissue dose density. The dose density value at primary target for all electrode configurations and input parameters do not exceed the threshold value (770 W/m), whereas the electric field value at the primary target satisfied the threshold value (100 V/m) on the system that used 4 plate-shaped electrodes and arm contour-shaped electrodes with an input voltage of 20 V, and at the input voltage 15 V, only 4 arm contour-shaped electrodes that satisfied the threshold value. An increase in input voltage, electrodes addition, and electrodes adjustment to skin contour shape result in an enhancement of electric field distribution and average electric field value at primary targets.

摘要

血癌是一种白细胞不受控制生长的病症。肿瘤治疗电场（TTF）是一种癌症治疗方式，它利用电场靶向恶性细胞。为了优化TTF的疗效，有必要通过改变电极配置和输入参数来研究电场分布。这能够在增强目标区域电场强度的同时，将敏感区域的强度降至最低。利用COMSOL Multiphysics 5.4软件，通过模拟具有不同电极配置和输入参数的臂部模型来进行电场分布分析。此外，还进行了研究以评估组织剂量密度。所有电极配置和输入参数在主要靶点处的剂量密度值均未超过阈值（770 W/m），而在使用4个板状电极和臂轮廓形状电极且输入电压为20 V的系统中，主要靶点处的电场值满足阈值（100 V/m），在输入电压为15 V时，只有4个臂轮廓形状电极满足阈值。输入电压的增加、电极的添加以及将电极调整为皮肤轮廓形状会导致主要靶点处的电场分布和平均电场值增强。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/4d514f73328c/21_e210013-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/fa506267f4b6/21_e210013-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/dc332184ea62/21_e210013-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/12d9bf0be48c/21_e210013-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/5c9f4fe0b2ae/21_e210013-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/36be03fee33f/21_e210013-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/89c0b1f88a7d/21_e210013-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/21ca7cab9689/21_e210013-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/eb523f0ca30f/21_e210013-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/756a587e412f/21_e210013-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/878ab5df84ad/21_e210013-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/4d514f73328c/21_e210013-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/fa506267f4b6/21_e210013-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/dc332184ea62/21_e210013-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/12d9bf0be48c/21_e210013-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/5c9f4fe0b2ae/21_e210013-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/36be03fee33f/21_e210013-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/89c0b1f88a7d/21_e210013-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/21ca7cab9689/21_e210013-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/eb523f0ca30f/21_e210013-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/756a587e412f/21_e210013-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/878ab5df84ad/21_e210013-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/757b/11347819/4d514f73328c/21_e210013-g011.jpg

相似文献

1
Optimizing tumor treating fields for blood cancer therapy: Analysis of electric field distribution and dose density.优化用于血癌治疗的肿瘤治疗电场：电场分布与剂量密度分析
Biophys Physicobiol. 2024 Apr 18;21(2):e210013. doi: 10.2142/biophysico.bppb-v21.0013. eCollection 2024.
2
Optimization of multi-electrode implant configurations and programming for the delivery of non-ablative electric fields in intratumoral modulation therapy.用于肿瘤内调制治疗中无创电场递送的多电极植入配置及编程的优化
Med Phys. 2020 Nov;47(11):5441-5454. doi: 10.1002/mp.14496. Epub 2020 Oct 13.
3
Analytical and numerical quantification and comparison of the local electric field in the tissue for different electrode configurations.不同电极配置下组织中局部电场的分析与数值量化及比较。
Biomed Eng Online. 2007 Oct 15;6:37. doi: 10.1186/1475-925X-6-37.
4
Planning system for the optimization of electric field delivery using implanted electrodes for brain tumor control.使用植入电极控制脑肿瘤的电场递送优化规划系统。
Med Phys. 2022 Sep;49(9):6055-6067. doi: 10.1002/mp.15825. Epub 2022 Jul 10.
5
Influence of electrode configuration on the electric field distribution during transcutaneous spinal direct current stimulation of the cervical spine.电极配置对颈椎经皮脊髓直流电刺激期间电场分布的影响。
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:3121-3124. doi: 10.1109/EMBC.2016.7591390.
6
Electrical exposure analysis of galvanic-coupled intra-body communication based on the empirical arm models.基于经验臂模型的体域网中电流耦合的电暴露分析。
Biomed Eng Online. 2018 Jun 5;17(1):71. doi: 10.1186/s12938-018-0473-9.
7
Electroporation of the Liver: More Than 2 Concurrently Active, Curved Electrodes Allow New Concepts for Irreversible Electroporation and Electrochemotherapy.肝脏电穿孔：超过2个同时激活的弯曲电极可为不可逆电穿孔和电化学疗法带来新的理念。
Technol Cancer Res Treat. 2018 Jan 1;17:1533033818809994. doi: 10.1177/1533033818809994.
8
Educational application for visualization and analysis of electric field strength in multiple electrode electroporation.多电极电穿孔中电场强度可视化和分析的教育应用。
BMC Med Educ. 2012 Oct 30;12:102. doi: 10.1186/1472-6920-12-102.
9
EView: An electric field visualization web platform for electroporation-based therapies.EView：一个用于电穿孔治疗的电场可视化网络平台。
Comput Methods Programs Biomed. 2020 Dec;197:105682. doi: 10.1016/j.cmpb.2020.105682. Epub 2020 Aug 2.
10
[Simulation model of tumor-treating fields].[肿瘤治疗电场的模拟模型]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2024 Apr 25;41(2):360-367. doi: 10.7507/1001-5515.202306074.

本文引用的文献

1
Diagnosis and Treatment of Chronic Lymphocytic Leukemia: A Review.慢性淋巴细胞白血病的诊断与治疗：综述
JAMA. 2023 Mar 21;329(11):918-932. doi: 10.1001/jama.2023.1946.
2
Tumor Treating Fields (TTFields) Therapy Concomitant with Taxanes for Cancer Treatment.肿瘤电场（TTFields）疗法联合紫杉烷类药物用于癌症治疗。
Cancers (Basel). 2023 Jan 19;15(3):636. doi: 10.3390/cancers15030636.
3
Medicinal Plants with Anti-Leukemic Effects: A Review.具有抗白血病作用的药用植物：综述。
Molecules. 2021 May 7;26(9):2741. doi: 10.3390/molecules26092741.
4
Tumour treating fields therapy for glioblastoma: current advances and future directions.肿瘤电场治疗胶质母细胞瘤：当前进展和未来方向。
Br J Cancer. 2021 Feb;124(4):697-709. doi: 10.1038/s41416-020-01136-5. Epub 2020 Nov 4.
5
Tumor treating fields in the management of Glioblastoma: opportunities for advanced imaging.肿瘤治疗电场在胶质母细胞瘤治疗中的应用：高级影像学的机遇。
Cancer Imaging. 2019 Nov 29;19(1):76. doi: 10.1186/s40644-019-0259-8.
6
Correlation of Tumor Treating Fields Dosimetry to Survival Outcomes in Newly Diagnosed Glioblastoma: A Large-Scale Numerical Simulation-Based Analysis of Data from the Phase 3 EF-14 Randomized Trial.肿瘤治疗电场剂量学与新诊断胶质母细胞瘤生存结局的相关性：基于 3 期 EF-14 随机试验数据的大规模数值模拟分析。
Int J Radiat Oncol Biol Phys. 2019 Aug 1;104(5):1106-1113. doi: 10.1016/j.ijrobp.2019.04.008. Epub 2019 Apr 23.
7
Tumor-Treating Fields: A Fourth Modality in Cancer Treatment.肿瘤电场治疗：癌症治疗的第四种模式。
Clin Cancer Res. 2018 Jan 15;24(2):266-275. doi: 10.1158/1078-0432.CCR-17-1117. Epub 2017 Aug 1.
8
Acute lymphoblastic leukemia: a comprehensive review and 2017 update.急性淋巴细胞白血病：全面综述及2017年更新
Blood Cancer J. 2017 Jun 30;7(6):e577. doi: 10.1038/bcj.2017.53.
9
Improving Tumor Treating Fields Treatment Efficacy in Patients With Glioblastoma Using Personalized Array Layouts.利用个体化微阵列设计提高胶质母细胞瘤肿瘤电场治疗的疗效。
Int J Radiat Oncol Biol Phys. 2016 Apr 1;94(5):1137-43. doi: 10.1016/j.ijrobp.2015.11.042. Epub 2015 Dec 14.
10
Tumor treating fields perturb the localization of septins and cause aberrant mitotic exit.肿瘤治疗电场扰乱了septin蛋白的定位并导致异常的有丝分裂退出。
PLoS One. 2015 May 26;10(5):e0125269. doi: 10.1371/journal.pone.0125269. eCollection 2015.