Cory-Slechta A
Division of Toxicology, University of Rochester, School of Medicine and Dentistry, NY 14642.
Sci Total Environ. 1988 Jun 1;71(3):433-40. doi: 10.1016/0048-9697(88)90215-x.
In accord with evidence from human studies, vulnerability of the rat to lead can be shown to extend to exposures initiated beyond the prenatal/neonatal stage of development. Chronic postweaning exposure to lead acetate in drinking water produces characteristic changes in learned behaviour maintained by food reward. These performance effects are related to both exposure concentration and duration. Correlations between biological exposure indices and behavioral changes may be improved by focusing on the maximal behavioral effect and the use of biological indices which reflect cumulative rather than recent exposure. Reversibility of lead-induced changes in behaviour depend upon exposure level; higher exposure level effects linger long after exposure ends despite marked reductions in brain lead.
与人体研究的证据一致，大鼠对铅的易感性可表现为在发育的产前/新生儿期之后开始接触也会受到影响。断奶后长期饮用含醋酸铅的水会使以食物奖励维持的学习行为产生特征性变化。这些行为影响与接触浓度和持续时间都有关。通过关注最大行为效应以及使用反映累积而非近期接触的生物指标，生物接触指标与行为变化之间的相关性可能会得到改善。铅诱导的行为变化的可逆性取决于接触水平；尽管脑铅含量显著降低，但较高接触水平的影响在接触结束后仍会持续很长时间。
