Chrobak Adrian Andrzej, Bohaterewicz Bartosz, Sobczak Anna Maria, Marszał-Wiśniewska Magdalena, Tereszko Anna, Krupa Anna, Ceglarek Anna, Fafrowicz Magdalena, Bryll Amira, Marek Tadeusz, Dudek Dominika, Siwek Marcin
Department of Adult Psychiatry, Jagiellonian University Medical College, Kopernika st. 21a, 31-501 Kraków, Poland.
Department of Psychology of Individual Differences, Psychological Diagnosis and Psychometrics, Faculty of Psychology in Warsaw, SWPS University of Social Sciences and Humanities, Chodakowska st. 19/31, 03-815 Warsaw, Poland.
Brain Sci. 2021 May 7;11(5):599. doi: 10.3390/brainsci11050599.
The goal of this paper is to investigate the baseline brain activity in euthymic bipolar disorder (BD) patients by comparing it to healthy controls (HC) with the use of a variety of resting state functional magnetic resonance imaging (rs-fMRI) analyses, such as amplitude of low frequency fluctuations (ALFF), fractional ALFF (f/ALFF), ALFF-based functional connectivity (FC), and r egional homogeneity (ReHo). We hypothesize that above-mentioned techniques will differentiate BD from HC indicating dissimilarities between the groups within different brain structures. Forty-two participants divided into two groups of euthymic BD patients (n = 21) and HC (n = 21) underwent rs-fMRI evaluation. Typical band ALFF, slow-4, slow-5, f/ALFF, as well as ReHo indexes were analyzed. Regions with altered ALFF were chosen as ROI for seed-to-voxel analysis of FC. As opposed to HC, BD patients revealed: increased ALFF in left insula; increased slow-5 in left middle temporal pole; increased f/ALFF in left superior frontal gyrus, left superior temporal gyrus, left middle occipital gyrus, right putamen, and bilateral thalamus. There were no significant differences between BD and HC groups in slow-4 band. Compared to HC, the BD group presented higher ReHo values in the left superior medial frontal gyrus and lower ReHo values in the right supplementary motor area. FC analysis revealed significant hyper-connectivity within the BD group between left insula and bilateral middle frontal gyrus, right superior parietal gyrus, right supramarginal gyrus, left inferior parietal gyrus, left cerebellum, and left supplementary motor area. To our best knowledge, this is the first rs-fMRI study combining ReHo, ALFF, f/ALFF, and subdivided frequency bands (slow-4 and slow-5) in euthymic BD patients. ALFF, f/ALFF, slow-5, as well as REHO analysis revealed significant differences between two studied groups. Although results obtained with the above methods enable to identify group-specific brain structures, no overlap between the brain regions was detected. This indicates that combination of foregoing rs-fMRI methods may complement each other, revealing the bigger picture of the complex resting state abnormalities in BD.
本文的目的是通过使用多种静息态功能磁共振成像（rs-fMRI）分析方法，如低频波动幅度（ALFF）、分数ALFF（f/ALFF）、基于ALFF的功能连接（FC）和局部一致性（ReHo），将双相情感障碍（BD）缓解期患者的基线脑活动与健康对照（HC）进行比较，以此来研究BD缓解期患者的基线脑活动。我们假设上述技术能够区分BD患者和HC，表明不同脑结构组之间存在差异。42名参与者被分为两组，即BD缓解期患者组（n = 21）和HC组（n = 21），并接受了rs-fMRI评估。分析了典型频段的ALFF、慢波4、慢波5、f/ALFF以及ReHo指数。将ALFF改变的区域选为感兴趣区（ROI），用于FC的种子点到体素分析。与HC相比，BD患者表现出：左侧岛叶的ALFF增加；左侧颞中极的慢波5增加；左侧额上回、左侧颞上回、左侧枕中回、右侧壳核和双侧丘脑的f/ALFF增加。BD组和HC组在慢波4频段没有显著差异。与HC相比，BD组在左侧额内侧上回的ReHo值较高，而在右侧辅助运动区的ReHo值较低。FC分析显示，BD组内左侧岛叶与双侧额中回、右侧顶上小叶、右侧缘上回、左侧顶下小叶、左侧小脑和左侧辅助运动区之间存在显著的高连接性。据我们所知，这是第一项在BD缓解期患者中结合ReHo、ALFF、f/ALFF和细分频段（慢波4和慢波5）的rs-fMRI研究。ALFF、f/ALFF、慢波5以及ReHo分析显示，两个研究组之间存在显著差异。尽管上述方法获得的结果能够识别特定组的脑结构，但未检测到脑区之间的重叠。这表明上述rs-fMRI方法的组合可能会相互补充，揭示BD复杂静息态异常的全貌。
