Baldino F, O'Kane T M, Fitzpatrick-McElligott S, Wolfson B
Medical Products Department, E. I. du Pont de Nemours & Company, Wilmington, DE 19898.
Science. 1988 Aug 19;241(4868):978-81. doi: 10.1126/science.3406747.
Previous studies have shown that adrenalectomy augments arginine vasopressin (AVP) messenger RNA levels in the adult paraventricular nucleus. It is now demonstrated that unilateral lesions in the lateral septal nucleus enhance the adrenalectomy-induced expression of AVP mRNA. This effect was entirely ipsilateral to the lesion and most prominent in the rostral paraventricular nucleus and related nuclei. Moreover, AVP and AVP mRNA were found to be colocalized with oxytocin in a few neurons. These results indicate that mRNA expression is modulated by synaptic influences and raise the possibility that synaptically mediated selection of neuronal phenotypes is a dynamic feature of the mature central nervous system.
以往的研究表明，肾上腺切除术可提高成年动物室旁核中精氨酸加压素（AVP）信使核糖核酸的水平。现已证明，外侧隔核的单侧损伤可增强肾上腺切除术诱导的AVP信使核糖核酸的表达。这种效应完全是损伤同侧的，且在室旁核前部及相关核团中最为显著。此外，还发现少数神经元中AVP及其信使核糖核酸与催产素共定位。这些结果表明，信使核糖核酸的表达受突触影响的调节，并增加了突触介导的神经元表型选择是成熟中枢神经系统动态特征的可能性。
