School of Chemical Engineering, University of Science and Technology Liaoning, Anshan 114051, China.
School of Pharmacy, Xinxiang University, Xinxiang 453000, China.
Molecules. 2021 May 17;26(10):2969. doi: 10.3390/molecules26102969.
A [3 + 2] 1,3-Dipolar cycloaddition of ,-cyclic azomethine imines with allyl alkyl ketones has been achieved. The reaction proceeds under mild conditions and tolerates a wide range of functional groups. An array of tetrahydroisoquinoline derivatives is generally constructed with good diastereoselectivities and enantioselectivities (up to >25:1 dr, >95% ee). Moreover, the absolute configuration of the product was previously determined by using the quantum electronic circular dichroism calculation and ECD spectrum method.
[3 + 2] 1,3-偶极环加成反应已应用于 -环状亚甲胺叶立德与烯丙基烷基酮的反应。该反应在温和条件下进行，并能耐受广泛的官能团。一系列四氢异喹啉衍生物通常以良好的非对映选择性和对映选择性（高达>25:1 dr，>95%ee）构建。此外，通过使用量子电子圆二色性计算和 ECD 光谱方法，先前已确定了产物的绝对构型。
