Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, The College of Life Sciences, Northwest University, Xi'an 710069, P. R. China.
School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
Org Lett. 2021 Jan 1;23(1):140-144. doi: 10.1021/acs.orglett.0c03858. Epub 2020 Dec 22.
An efficient enantioselective hydrogenation of sterically hindered cyclic imines catalyzed by the Ir-Bu-ax-Josiphos complex has been described, producing a series of useful chiral bulky tetrahydroisoquinoline analogs in high isolated yields (85-96%) with good to excellent enantioselectivities (74-99% ). This transformation provided highly straightforward access to the useful derivatives of tetrahydroisoquinolines, which are of great potential value in drug molecule and natural product research.
一种由 Ir-Bu-ax-Josiphos 配合物催化的立体位阻环状亚胺的高效对映选择性氢化反应已经被描述，该反应以高分离产率（85-96%）和优异到极好的对映选择性（74-99%）得到了一系列有用的手性大位阻四氢异喹啉类似物。这种转化为四氢异喹啉的有用衍生物提供了非常直接的途径，这些衍生物在药物分子和天然产物研究中具有巨大的潜在价值。
