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肥胖症手术后的妊娠:. 中对于小于胎龄儿危险因素的巢式病例对照研究

Pregnancy after Bariatric Surgery: A Nested Case-Control Study of Risk Factors for Small for Gestational Age Babies in .

机构信息

Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4AX, UK.

Department of Obstetrics and Gynaecology, University Hospitals Leuven, 3000 Leuven, Belgium.

出版信息

Nutrients. 2021 May 17;13(5):1699. doi: 10.3390/nu13051699.

Abstract

Bariatric surgery prior to pregnancy is a significant risk factor for small for gestational age (SGA) babies. This case-control study investigated differences between mothers delivering an SGA baby following bariatric surgery, compared to those delivering an appropriate for gestational age (AGA) baby. Out of 129 babies born to mothers in the AURORA cohort study, 25 were SGA (<10th percentile) and 97 were AGA (10th-90th percentile). Higher gestational weight gain (GWG) was significantly associated with decreased odds of SGA (aOR per kg 0.92, 95% CI 0.85-0.99). According to the Institute of Medicine GWG guidelines, 44% of SGA mothers had 'inadequate' GWG compared to 17% of AGA mothers. Nearly half of the mothers had 'excessive' GWG yet still gave birth to an SGA or AGA baby. Mothers of SGA babies lost more weight following bariatric surgery (45.6 ± 14.4 kg vs. 39.0 ± 17.9 kg). Women who reported receiving nutritional advice following bariatric surgery were significantly less likely to have an SGA baby (aOR 0.15, 95% CI 0.0.4-0.55). Women with a history of bariatric surgery should be provided with specialized support before and during pregnancy to encourage adequate nutritional intake and weight gain to support healthy fetal growth.

摘要

孕前接受减重手术是导致胎儿小于胎龄儿(SGA)的一个重要危险因素。本病例对照研究比较了接受减重手术的孕妇所生 SGA 儿与适当胎龄儿(AGA)儿的差异。在 AURORA 队列研究的 129 名婴儿中,有 25 名是 SGA(<第 10 百分位数),97 名是 AGA(第 10-90 百分位数)。较高的孕期体重增长(GWG)与 SGA 的发生几率降低显著相关(每公斤的优势比 aOR 为 0.92,95%CI 为 0.85-0.99)。根据美国医学研究所 GWG 指南,44%的 SGA 母亲 GWG 不足,而 AGA 母亲只有 17%。近一半的母亲 GWG 过多,但仍产下了 SGA 或 AGA 儿。接受减重手术的 SGA 婴儿母亲在术后体重减轻更多(45.6 ± 14.4 kg 比 39.0 ± 17.9 kg)。术后接受营养咨询的母亲生下 SGA 儿的几率显著降低(aOR 为 0.15,95%CI 为 0.0.4-0.55)。有减重手术史的女性在备孕和妊娠期间应得到专门的支持,以鼓励其摄入充足的营养并增加体重,从而支持胎儿健康生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c49e/8156275/4fdbd85ecf23/nutrients-13-01699-g001.jpg

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