Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
Weight Management Unit, NMC Royal Khalifa Hospital, Abu Dhabi P.O. Box 35233, United Arab Emirates.
Nutrients. 2023 Dec 25;16(1):72. doi: 10.3390/nu16010072.
Metabolic bariatric surgery (MBS) helps reduce comorbidities, such as hypertension and gestational diabetes, and is more effective than diet management for women with obesity-related health issues. Vitamin B, vitamin D, and iron play important roles in ensuring the health of a neonate. However, pregnancies occurring after MBS may face complications related to micronutrient deficiencies, particularly of vitamins B and D and iron. This study aimed to investigate the vitamin B, vitamin D, ferritin, and iron status of pregnant women who underwent MBS compared with women without MBS history. The study included 217 pregnant women (105 with a history of MBS and 112 without a history of MBS) who visited a major maternity hospital in Abu Dhabi, United Arab Emirates (UAE) between July 2021 and November 2022. The maternal vitamin B, vitamin D, iron, and ferritin levels were measured twice, initially during the first or second trimester and subsequently during the third trimester. The iron was measured once during the pregnancy. Vitamin B deficiency was higher among pregnant women with MBS history compared to non-bariatric pregnant women (24.4% vs. 3.9%, < 0.001). Women with a history of MBS had a higher prevalence of vitamin D deficiency (62.3% vs. 37.7%, < 0.002). Linear regression analysis indicated that vitamin B levels decreased by 55 pg/mL in women with a history of MBS and by 4.6 pg/mL with a unit increase in body mass index (kg/m). Furthermore, vitamin D levels in women with a history of MBS decreased by 4.9 ng/mL during pregnancy. Metabolic bariatric surgery is associated with vitamin B, vitamin D, and iron deficiencies during pregnancy.
代谢减重手术（MBS）有助于减少合并症，如高血压和妊娠糖尿病，并且对于肥胖相关健康问题的女性来说，比饮食管理更有效。维生素 B、维生素 D 和铁在确保新生儿健康方面发挥着重要作用。然而，MBS 后发生的妊娠可能会面临与微量营养素缺乏相关的并发症，特别是维生素 B 和 D 以及铁的缺乏。本研究旨在调查与没有 MBS 史的女性相比，接受 MBS 的孕妇的维生素 B、维生素 D、铁蛋白和铁状况。该研究纳入了 217 名孕妇（105 名有 MBS 史，112 名无 MBS 史），她们于 2021 年 7 月至 2022 年 11 月期间在阿拉伯联合酋长国阿布扎比的一家主要妇产医院就诊。两次测量了产妇的维生素 B、维生素 D、铁和铁蛋白水平，最初在孕早期或孕中期，随后在孕晚期进行。在怀孕期间仅测量了一次铁。与非减重孕妇相比，有 MBS 史的孕妇维生素 B 缺乏的发生率更高（24.4%比 3.9%，<0.001）。有 MBS 史的女性维生素 D 缺乏的发生率更高（62.3%比 37.7%，<0.002）。线性回归分析表明，有 MBS 史的女性维生素 B 水平下降了 55pg/ml，体重指数（kg/m）每增加一个单位，维生素 B 水平下降 4.6pg/ml。此外，有 MBS 史的女性在怀孕期间维生素 D 水平下降了 4.9ng/ml。代谢减重手术与怀孕期间的维生素 B、维生素 D 和铁缺乏有关。
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