Ahl T, Albertsson-Wikland K, Kalén R
Department of Orthopaedics, Karolinska Institutet, Danderyd Hospital, Danderyd, Sweden.
Spine (Phila Pa 1976). 1988 Feb;13(2):139-42. doi: 10.1097/00007632-198802000-00001.
Spontaneous growth hormone (GH) secretion during a 24-hour period was analyzed in 16 girls with progressive adolescent idiopathic scoliosis (AIS) and in 26 healthy controls. All the girls were in puberty. Episodic secretion of GH both during the day and night was found in all girls. Both AIS girls and controls in pubertal stages 3 and 4 showed an increase of measured GH compared with girls in pubertal stage 2. Among the girls in pubertal stage 2, more GH was secreted in the AIS group than in the controls. It is concluded that it is only in early puberty (stage 2) that girls with AIS have a higher endogenous secretion of GH than normal girls, which implies an earlier growth spurt in scoliotic girls.
对16名患有进行性青少年特发性脊柱侧弯（AIS）的女孩和26名健康对照者进行了24小时内自发性生长激素（GH）分泌分析。所有女孩均处于青春期。所有女孩白天和夜间均发现有GH的脉冲式分泌。处于青春期3期和4期的AIS女孩和对照者与青春期2期的女孩相比，所测GH均有所增加。在青春期2期的女孩中，AIS组分泌的GH比对照组更多。得出的结论是，仅在青春期早期（2期），患有AIS的女孩内源性GH分泌高于正常女孩，这意味着脊柱侧弯女孩的生长突增更早。
