Willner S, Nilsson K O, Kastrup K, Bergstrand C G
Acta Paediatr Scand. 1976 Sep;65(5):547-52. doi: 10.1111/j.1651-2227.1976.tb04930.x.
Girls with adolescent idiopathic scoliosis are taller than nonscoliotic girls of the same age. This observation may be related to factors regulating longitudinal growth. Plasma growth hormone was determined in a group of scoliotic girls by double antibody radioimmunoassay under the following conditions: 1) Insulin induced hypoglycemia, 2) glucose tolerance test, 3) exercise. Somatomedin A was determined by a method based on the ability of serum to stimulate the incorporation of radioactive sulphate in embryonic chick cartilage. The results were compared with those obtained in a control group of healthy nonscoliotic girls of comparable age. After overnight fasting and after at least one hour's rest the basal growth hormone level was 9.8+/-11.1 (+/-S.D.) ng/ml in the scoliotic girls (n=48) and 2.2+/-1.1 ng/ml in the controls (n=15). This difference is significant. In the hypoglycemia test the peak growth hormone level tended to be higher in the scoliotic girls but the difference is not significant. In the exercise test the maximal value was reached at different times in the two groups: at 20 min after start of the exercise in the scoliotic girls (n=14, 17.3+/-11.8 ng/ml) and at 40 min in the controls (n=9, 16.0+/-6.6 ng/ml). In the glucose tolerance test the growth hormone level was suppressed in both groups but the mean values tended to be higher during the first 120 min in the scoliotic girls. The serum somatomedin levels were higher in the group of scoliotic girls (n=19, 1.13+/-0.17 U/ml) than in the controls (n=14, 0.88+/-0.16 U/ml) and the difference is significant. The results obtained are difficult to interpret but suggest that growth hormone secretion is higher in girls with adolescent idiopathic scoliosis than in healthy girls of comparable age.
患有青少年特发性脊柱侧凸的女孩比同龄无脊柱侧凸的女孩更高。这一观察结果可能与调节纵向生长的因素有关。通过双抗体放射免疫分析法在以下条件下测定了一组脊柱侧凸女孩的血浆生长激素：1）胰岛素诱导低血糖；2）葡萄糖耐量试验；3）运动。通过基于血清刺激放射性硫酸盐掺入胚胎鸡软骨能力的方法测定生长调节素A。将结果与年龄相当的健康无脊柱侧凸女孩对照组的结果进行比较。在空腹过夜并至少休息一小时后，脊柱侧凸女孩（n = 48）的基础生长激素水平为9.8±11.1（±标准差）ng/ml，对照组（n = 15）为2.2±1.1 ng/ml。这种差异具有显著性。在低血糖试验中，脊柱侧凸女孩的生长激素峰值水平往往较高，但差异不显著。在运动试验中，两组达到最大值的时间不同：脊柱侧凸女孩（n = 14）在运动开始后20分钟达到最大值（17.3±11.8 ng/ml），对照组（n = 9）在40分钟达到最大值（16.0±6.6 ng/ml）。在葡萄糖耐量试验中，两组的生长激素水平均受到抑制，但在最初120分钟内，脊柱侧凸女孩的平均值往往较高。脊柱侧凸女孩组（n = 19，1.13±0.17 U/ml）的血清生长调节素水平高于对照组（n = 14，0.88±0.16 U/ml），差异具有显著性。所得结果难以解释，但表明患有青少年特发性脊柱侧凸的女孩的生长激素分泌高于年龄相当的健康女孩。
