Department of Genetics and Biotechnology, Saint-Petersburg State University, Universitetskaya Emb. 7/9, 199034 St. Petersburg, Russia.
A. Tsyb Medical Radiological Research Center-Branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, Koroleva Str. 4, 249036 Obninsk, Russia.
Cells. 2021 May 10;10(5):1144. doi: 10.3390/cells10051144.
() is an orthologue of the () genes in different The known function of genes is the export of various mRNAs from the nucleus to the cytoplasm. The cytoplasmic localization of the SBR protein indicates that the nuclear export function is not the only function of this gene in RNA-binding protein SBR enriches the nucleus and cytoplasm of specific neurons and glial cells. In mutant males, the disturbance of medulla boundaries correlates with the defects of photoreceptor axons pathfinding, axon bundle individualization, and developmental neurodegeneration. RNA-binding protein SBR participates in processes allowing axons to reach and identify their targets.
SBR 蛋白是不同物种中与 基因的同源物。已知 基因的功能是将各种 mRNA 从细胞核输出到细胞质。SBR 蛋白的细胞质定位表明该基因在核输出功能之外还具有其他功能。SBR 是一种 RNA 结合蛋白，它在特定神经元和神经胶质细胞的核和细胞质中富集。在 突变雄性中，延髓边界的紊乱与光感受器轴突寻的缺陷、轴突束个体化和发育性神经退行性变相关。RNA 结合蛋白 SBR 参与允许轴突到达并识别其靶标的过程。
