Wittenberg D F, Padayachi T, Norman R J
Department of Paediatrics and Child Health, University of Natal, Durban.
S Afr Med J. 1988 Aug 20;74(4):181-3.
A 16-year-old boy with 47,XXY chromosomal complement (Klinefelter's syndrome) presented with delayed puberty and apparent gonadotrophin deficiency. Despite an inadequate growth hormone response to insulin-induced hypoglycaemia and to L-dopa administration, his somatic growth was appropriate for his delay in pubertal development, increasing markedly on testosterone treatment. Patients with Klinefelter's syndrome may have abnormalities of neuro-endocrine regulation.
