Kumanov P
Clinical Center of Endocrinology, Gerontology Higher Medical School, Sofia, Bulgaria.
Andrologia. 1995 Jan-Feb;27(1):41-5.
The reports published thus far on prolactin and thyrotrophin secretion in patients with Klinefelter's syndrome are controversial. The aim of the present study was to investigate the interrelation between prolactin on one hand, and hormones of the hypothalamic-pituitary-gonadal axis and thyrotrophin, on the other, in males with Klinefelter's syndrome. Fifteen patients with Klinefelter's syndrome, aged between 17 and 43 years, and 15 healthy males, aged 22-35 years, were studied. Mean +/- SD basal serum prolactin levels were 529.6 +/- 174.6 mU l-1 in the patients, and 270.1 +/- 113.0 mU l-1 in the control group (P < 0.001). Following 200 micrograms thyrotrophin releasing hormone, an enhanced prolactin response was seen in the males with Klinefelter's syndrome. There was no evidence of any of the well-known causes of hyperprolactinaemia. The response of thyrotrophin to thyrotrophin releasing hormone was more pronounced in Klinefelter patients in comparison with controls. Presumably, in Klinefelter's syndrome both alterations--of prolactin and thyrotrophin secretion--may be caused by decrease of testosterone levels or they could reflect a disturbance in neuroendocrine regulation with some neurotransmitter imbalance.
迄今为止，关于克兰费尔特综合征患者催乳素和促甲状腺激素分泌的报道存在争议。本研究的目的是探讨克兰费尔特综合征男性患者中催乳素与下丘脑 - 垂体 - 性腺轴激素及促甲状腺激素之间的相互关系。研究了15例年龄在17至43岁之间的克兰费尔特综合征患者和15例年龄在22至35岁之间的健康男性。患者组基础血清催乳素水平的均值±标准差为529.6±174.6 mU l-1，对照组为270.1±113.0 mU l-1（P < 0.001）。给予200微克促甲状腺激素释放激素后，克兰费尔特综合征男性患者出现催乳素反应增强。没有证据表明存在任何已知的高催乳素血症病因。与对照组相比，克兰费尔特综合征患者促甲状腺激素对促甲状腺激素释放激素的反应更为明显。推测在克兰费尔特综合征中，催乳素和促甲状腺激素分泌的改变可能是由睾酮水平降低引起的，或者它们可能反映了神经内分泌调节紊乱以及某些神经递质失衡。
